| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Geob_0937 | nnr | Geob_0937 | Geob_2942 | Cysteine hydrolase family protein. | (R)-NAD(P)H-hydrate epimerase and ADP-dependent (S)-NAD(P)H-hydrate dehydratase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific [...] | 0.571 |
| Geob_0937 | ridA | Geob_0937 | Geob_2146 | Cysteine hydrolase family protein. | Enamine/imine deaminase. | 0.472 |
| apt | gmk | Geob_3332 | Geob_2143 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.715 |
| apt | guaA | Geob_3332 | Geob_2182 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanosine-5'-monophosphate synthetase; Catalyzes the synthesis of GMP from XMP. | 0.882 |
| apt | ribD | Geob_3332 | Geob_2675 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.517 |
| apt | ridA | Geob_3332 | Geob_2146 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Enamine/imine deaminase. | 0.787 |
| gmk | apt | Geob_2143 | Geob_3332 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.715 |
| gmk | guaA | Geob_2143 | Geob_2182 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Guanosine-5'-monophosphate synthetase; Catalyzes the synthesis of GMP from XMP. | 0.967 |
| gmk | relA | Geob_2143 | Geob_2145 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GTP/GDP 3'-pyrophosphokinase and (p)ppGpp 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.958 |
| gmk | ribD | Geob_2143 | Geob_2675 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.534 |
| gmk | ridA | Geob_2143 | Geob_2146 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Enamine/imine deaminase. | 0.481 |
| gmk | tpi | Geob_2143 | Geob_2899 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.527 |
| guaA | apt | Geob_2182 | Geob_3332 | Guanosine-5'-monophosphate synthetase; Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.882 |
| guaA | gmk | Geob_2182 | Geob_2143 | Guanosine-5'-monophosphate synthetase; Catalyzes the synthesis of GMP from XMP. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.967 |
| guaA | ribD | Geob_2182 | Geob_2675 | Guanosine-5'-monophosphate synthetase; Catalyzes the synthesis of GMP from XMP. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.580 |
| guaA | ridA | Geob_2182 | Geob_2146 | Guanosine-5'-monophosphate synthetase; Catalyzes the synthesis of GMP from XMP. | Enamine/imine deaminase. | 0.449 |
| guaA | rph | Geob_2182 | Geob_3021 | Guanosine-5'-monophosphate synthetase; Catalyzes the synthesis of GMP from XMP. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.437 |
| guaA | tdcB | Geob_2182 | Geob_0703 | Guanosine-5'-monophosphate synthetase; Catalyzes the synthesis of GMP from XMP. | Threonine and serine dehydratase and deaminase, catabolic. | 0.431 |
| guaA | tpi | Geob_2182 | Geob_2899 | Guanosine-5'-monophosphate synthetase; Catalyzes the synthesis of GMP from XMP. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.404 |
| nnr | Geob_0937 | Geob_2942 | Geob_0937 | (R)-NAD(P)H-hydrate epimerase and ADP-dependent (S)-NAD(P)H-hydrate dehydratase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific [...] | Cysteine hydrolase family protein. | 0.571 |