STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ETK31840.1Acetolactate synthase. (174 aa)    
Predicted Functional Partners:
ETK31839.1
Acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate.
 
 0.999
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.999
ETK32804.1
Hypothetical protein; Belongs to the TPP enzyme family.
 
 0.997
ETK31853.1
Catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis.
 
 0.996
ETK31994.1
Hypothetical protein; Belongs to the TPP enzyme family.
 
 0.995
ETK36649.1
Acetolactate synthase; Belongs to the TPP enzyme family.
 
 0.994
ETK32334.1
Hypothetical protein; Belongs to the TPP enzyme family.
 
 0.994
ETK37363.1
Acetolactate synthase; Belongs to the TPP enzyme family.
 
 0.993
ETK37122.1
Hypothetical protein; Belongs to the TPP enzyme family.
 
 0.993
ETK31868.1
Pyruvate dehydrogenase; Catalyzes the formation of acetate from pyruvate; Belongs to the TPP enzyme family.
 
 0.990
Your Current Organism:
Microbispora sp. ATCC PTA5024
NCBI taxonomy Id: 316330
Other names: M. sp. ATCC PTA-5024, Microbispora sp. ATCC PTA-5024
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.