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polB protein (Escherichia coli K12 W3110) - STRING interaction network
"polB" - DNA polymerase II in Escherichia coli K12 W3110
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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polBDNA polymerase II; Thought to be involved in DNA repair and/or mutagenesis (783 aa)    
Predicted Functional Partners:
dnaN
DNA polymerase III, beta subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3’ to 5’ exonuclease activity. The beta chain is required for initiation of replication; once it is clamped onto DNA it slides freely (bidirectional and ATP- independent) along duplex DNA. Coordinates protein traffic at the replication fork, where it interacts with multiple DNA polymerases (366 aa)
     
  0.976
dinB
DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3’-5’ exonuclease (proofreading) activity. Overexpression of polIV results in increased frameshift mutagenesis. It is required for stationary-phase adaptive mutation, which provides the bacterium with flexibility in dealing with environmental stress, enhancing long-term survival and evolutionary fitness. May be i [...] (351 aa)
     
  0.958
polA
Fused DNA polymerase I 5’->3’ exonuclease, 3’->5’ polymerase and 3’->5’ exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 3’ to 5’ and 5’ to 3’ exonuclease activity. It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template (928 aa)
     
  0.935
umuC
DNA polymerase V, subunit C; Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template (422 aa)
     
  0.922
mutS
Methyl-directed mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity (853 aa)
     
 
  0.838
tif
DNA strand exchange and recombination protein with protease and nuclease activity; Required for homologous recombination and the bypass of mutagenic DNA lesions by the SOS response. Catalyzes ATP-driven homologous pairing and strand exchange of DNA molecules necessary for DNA recombinational repair. Catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. The SOS response controls an apoptotic-like death (ALD) induced (in the absence of t [...] (353 aa)
     
  0.827
cou
DNA gyrase, subunit B; DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state (PubMed-186775, PubMed-3031051, PubMed-1323022, PubMed-8248233, PubMed-7811004, PubMed-8621650, PubMed-9657678, PubMed-12051842, PubMed-12051843, PubMed-18642932, PubMed-19060136, PubMed-19965760, PubMed-22457353, PubMed-23294697, PubMed-20356737, PubMed-20675723, PubMed-23352267, PubMed-24386374, PubMed-25202966, PubMed-25849408). This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme t [...] (804 aa)
     
 
  0.819
gyrA
DNA gyrase (type II topoisomerase), subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state (PubMed-3031051, PubMed-186775, PubMed-7811004, PubMed-9148951, PubMed-12051842, PubMed-18642932, PubMed-19060136, PubMed-20356737, PubMed-22457353, PubMed-23294697, PubMed-19965760). This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli (PubMed-9334322). Gyrase catalyzes the interconversi [...] (875 aa)
     
 
  0.812
nrdA
Ribonucleoside diphosphate reductase 1, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox- active cysteines (761 aa)
     
 
  0.752
lig
DNA ligase, NAD(+)-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5’-phosphoryl and 3’-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (671 aa)
     
 
  0.718
Your Current Organism:
Escherichia coli K12 W3110
NCBI taxonomy Id: 316407
Other names: E. coli str. K-12 substr. W3110, Escherichia coli K12 W3110, Escherichia coli W3110, Escherichia coli str. K-12 substr. W3110, Escherichia coli str. K12 substr. W3110, Escherichia coli str. W3110, Escherichia coli strain W3110
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