STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tcr_1001Pyruvate dehydrogenase complex, E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (886 aa)    
Predicted Functional Partners:
Tcr_1002
Pyruvate dehydrogenase complex, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.999
Tcr_1003
TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment FAD-dependent pyridine nucleotide-disulphide oxidoreductase pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: bbr:BB2538 dihydrolipoamide dehydrogenase.
 
 0.999
Tcr_1491
PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: neu:NE0774 dihydrolipoamide dehydrogenase.
  
 
 0.958
Tcr_1709
2-oxoacid:acceptor oxidoreductase, alpha subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase pyruvate flavodoxin/ferredoxin oxidoreductase-like; KEGG: gka:GK1301 2-oxoglutarate synthase(2-oxoglutarate-ferredoxin oxidoreductase) alpha subunit.
     
 0.943
Tcr_0247
PFAM: pyruvate kinase; KEGG: vpa:VP2039 pyruvate kinase II; Belongs to the pyruvate kinase family.
  
 
 0.920
Tcr_1186
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
     
 0.912
Tcr_1710
TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate enzyme-like TPP-binding; KEGG: pai:PAE1558 2-oxoacid ferredoxin oxidoreductase beta subunit.
     
 0.909
Tcr_1607
PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: ana:alr0058 D-lactate dehydrogenase.
     
 0.907
pgi
PFAM: phosphoglucose isomerase (PGI); KEGG: aci:ACIAD0101 glucose-6-phosphate isomerase; Belongs to the GPI family.
  
 
 0.867
Tcr_0248
Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
   
 
 0.835
Your Current Organism:
Hydrogenovibrio crunogenus
NCBI taxonomy Id: 317025
Other names: H. crunogenus XCL-2, Hydrogenovibrio crunogenus XCL-2, Thiomicrospira crunogena XCL-2
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.