PROH_10985 protein (Prochlorothrix hollandica)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

PROH_10985

Unannotated protein. (178 aa)

Predicted Functional Partners:

PROH_01270

0.774

PROH_13375

0.773

PROH_08910

0.772

PROH_09415

0.771

PROH_04085

0.771

thf1

0.771

PROH_20875

0.767

PROH_14470

0.765

PROH_19295

0.764

PROH_01330

0.763

Your Current Organism:

Prochlorothrix hollandica

NCBI taxonomy Id: 317619
Other names: P. hollandica PCC 9006 = CALU 1027, Prochlorothrix hollandica CCMP34, Prochlorothrix hollandica CCMP682, Prochlorothrix hollandica LI-2 ACC15-2, Prochlorothrix hollandica PCC 9006, Prochlorothrix hollandica PCC 9006 = CALU 1027, Prochlorothrix hollandica PCT-31, Prochlorothrix hollandica SAG 10.89

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PROH_01270	PROH_01330	GCA_000332315_03424	GCA_000332315_03437	Unannotated protein.	Unannotated protein; Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.	0.758
PROH_01270	PROH_04085	GCA_000332315_03424	GCA_000332315_04099	Unannotated protein.	Unannotated protein.	0.775
PROH_01270	PROH_08910	GCA_000332315_03424	GCA_000332315_00585	Unannotated protein.	Unannotated protein.	0.774
PROH_01270	PROH_09415	GCA_000332315_03424	GCA_000332315_00641	Unannotated protein.	Unannotated protein.	0.771
PROH_01270	PROH_10985	GCA_000332315_03424	GCA_000332315_00970	Unannotated protein.	Unannotated protein.	0.774
PROH_01270	PROH_13375	GCA_000332315_03424	GCA_000332315_01805	Unannotated protein.	Unannotated protein.	0.766
PROH_01270	PROH_14470	GCA_000332315_03424	GCA_000332315_02025	Unannotated protein.	Unannotated protein.	0.758
PROH_01270	PROH_19295	GCA_000332315_03424	GCA_000332315_01333	Unannotated protein.	Unannotated protein.	0.540
PROH_01270	PROH_20875	GCA_000332315_03424	GCA_000332315_03045	Unannotated protein.	Unannotated protein.	0.724
PROH_01270	thf1	GCA_000332315_03424	GCA_000332315_04611	Unannotated protein.	Unannotated protein; May be involved in photosynthetic membrane biogenesis.	0.771
PROH_01330	PROH_01270	GCA_000332315_03437	GCA_000332315_03424	Unannotated protein; Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.	Unannotated protein.	0.758
PROH_01330	PROH_04085	GCA_000332315_03437	GCA_000332315_04099	Unannotated protein; Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.	Unannotated protein.	0.764
PROH_01330	PROH_08910	GCA_000332315_03437	GCA_000332315_00585	Unannotated protein; Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.	Unannotated protein.	0.753
PROH_01330	PROH_09415	GCA_000332315_03437	GCA_000332315_00641	Unannotated protein; Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.	Unannotated protein.	0.705
PROH_01330	PROH_10985	GCA_000332315_03437	GCA_000332315_00970	Unannotated protein; Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.	Unannotated protein.	0.763
PROH_01330	PROH_13375	GCA_000332315_03437	GCA_000332315_01805	Unannotated protein; Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.	Unannotated protein.	0.773
PROH_01330	PROH_14470	GCA_000332315_03437	GCA_000332315_02025	Unannotated protein; Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.	Unannotated protein.	0.541
PROH_01330	PROH_19295	GCA_000332315_03437	GCA_000332315_01333	Unannotated protein; Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.	Unannotated protein.	0.613
PROH_01330	PROH_20875	GCA_000332315_03437	GCA_000332315_03045	Unannotated protein; Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.	Unannotated protein.	0.687
PROH_01330	thf1	GCA_000332315_03437	GCA_000332315_04611	Unannotated protein; Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.	Unannotated protein; May be involved in photosynthetic membrane biogenesis.	0.758

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Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.868

expected number of edges:

12

PPI enrichment p-value:

0.0469

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009089

Lysine biosynthetic process via diaminopimelate

6 of 16

1.93

3.16

5.50e-08

GO:0043648

Dicarboxylic acid metabolic process

7 of 32

1.69

2.75

4.50e-08

GO:0019877

Diaminopimelate biosynthetic process

4 of 10

1.95

2.31

1.35e-05

GO:0043650

Dicarboxylic acid biosynthetic process

5 of 21

1.73

2.28

3.57e-06

GO:0008652

Cellular amino acid biosynthetic process

8 of 91

1.3

1.79

1.28e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030170

Pyridoxal phosphate binding

4 of 21

1.63

1.3

0.0015

GO:0008483

Transaminase activity

3 of 15

1.65

1.03

0.0074

GO:0003824

Catalytic activity

11 of 1196

0.31

0.25

0.0340

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 923

0.39

0.27

0.0415

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1636

Lysine biosynthesis, and Threonine biosynthetic process

8 of 13

2.14

5.31

5.32e-13

CL:1638

Diaminopimelate biosynthesis

5 of 5

2.35

3.96

1.19e-08

CL:1596

Cysteine and methionine metabolism, and Lysine biosynthesis

9 of 38

1.73

3.79

2.13e-12

CL:1416

Biosynthesis of amino acids, and Oxidoreductase activity

10 of 128

1.24

1.91

3.07e-10

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00300

Lysine biosynthesis

10 of 31

1.86

5.03

5.66e-16

map01230

Biosynthesis of amino acids

11 of 121

1.31

2.32

3.58e-13

map00261

Monobactam biosynthesis

3 of 5

2.13

2.04

9.96e-05

map01110

Biosynthesis of secondary metabolites

11 of 306

0.91

1.06

4.70e-09

map01120

Microbial metabolism in diverse environments

6 of 179

0.88

0.73

0.00099

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0457

Lysine biosynthesis

7 of 7

2.35

5.6

1.78e-12

KW-0220

Diaminopimelate biosynthesis

5 of 5

2.35

3.94

1.34e-08

KW-0032

Aminotransferase

3 of 14

1.68

1.28

0.0019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01041

DegT/DnrJ/EryC1/StrS aminotransferase family

3 of 4

2.23

1.62

0.00083

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004838

Aminotransferases, class-I, pyridoxal-phosphate-binding site

3 of 4

2.23

1.39

0.0024

IPR004839

Aminotransferase, class I/classII

3 of 9

1.87

1.09

0.0075

IPR015424

Pyridoxal phosphate-dependent transferase

3 of 21

1.51

0.66

0.0446

IPR015422

Pyridoxal phosphate-dependent transferase, small domain

3 of 21

1.51

0.66

0.0446

IPR015421

Pyridoxal phosphate-dependent transferase, major domain

3 of 21

1.51

0.66

0.0446

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