node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sfri_1035 | birA | Sfri_1035 | Sfri_0132 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.746 |
Sfri_1035 | rlmL | Sfri_1035 | Sfri_2661 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Putative RNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.731 |
Sfri_1035 | uppS | Sfri_1035 | Sfri_1274 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Undecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.544 |
Sfri_2658 | Sfri_2659 | Sfri_2658 | Sfri_2659 | KEGG: son:SO1854 hypothetical protein. | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: son:SO1853 ABC transporter, ATP-binding protein. | 0.721 |
Sfri_2658 | Sfri_2660 | Sfri_2658 | Sfri_2660 | KEGG: son:SO1854 hypothetical protein. | PFAM: glutaredoxin 2; KEGG: son:SO1852 hypothetical protein. | 0.721 |
Sfri_2658 | rlmL | Sfri_2658 | Sfri_2661 | KEGG: son:SO1854 hypothetical protein. | Putative RNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.770 |
Sfri_2659 | Sfri_2658 | Sfri_2659 | Sfri_2658 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: son:SO1853 ABC transporter, ATP-binding protein. | KEGG: son:SO1854 hypothetical protein. | 0.721 |
Sfri_2659 | Sfri_2660 | Sfri_2659 | Sfri_2660 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: son:SO1853 ABC transporter, ATP-binding protein. | PFAM: glutaredoxin 2; KEGG: son:SO1852 hypothetical protein. | 0.795 |
Sfri_2659 | rlmL | Sfri_2659 | Sfri_2661 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: son:SO1853 ABC transporter, ATP-binding protein. | Putative RNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.857 |
Sfri_2660 | Sfri_2658 | Sfri_2660 | Sfri_2658 | PFAM: glutaredoxin 2; KEGG: son:SO1852 hypothetical protein. | KEGG: son:SO1854 hypothetical protein. | 0.721 |
Sfri_2660 | Sfri_2659 | Sfri_2660 | Sfri_2659 | PFAM: glutaredoxin 2; KEGG: son:SO1852 hypothetical protein. | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: son:SO1853 ABC transporter, ATP-binding protein. | 0.795 |
Sfri_2660 | rlmL | Sfri_2660 | Sfri_2661 | PFAM: glutaredoxin 2; KEGG: son:SO1852 hypothetical protein. | Putative RNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.814 |
argS | pnp | Sfri_3762 | Sfri_0995 | KEGG: son:SO4123 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | 0.595 |
argS | rlmL | Sfri_3762 | Sfri_2661 | KEGG: son:SO4123 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | Putative RNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.585 |
argS | thiI | Sfri_3762 | Sfri_2785 | KEGG: son:SO4123 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.419 |
birA | Sfri_1035 | Sfri_0132 | Sfri_1035 | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.746 |
birA | rlmL | Sfri_0132 | Sfri_2661 | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Putative RNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.562 |
pnp | argS | Sfri_0995 | Sfri_3762 | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | KEGG: son:SO4123 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | 0.595 |
pnp | rlmL | Sfri_0995 | Sfri_2661 | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | Putative RNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.606 |
pnp | uppS | Sfri_0995 | Sfri_1274 | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | Undecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.713 |