STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sfri_3552Methionine repressor, MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. (104 aa)    
Predicted Functional Partners:
seqA
seqA protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
  
    0.798
Sfri_3550
KEGG: son:SO4055 aspartokinase II/homoserine dehydrogenase, methionine-sensitive; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; homoserine dehydrogenase; homoserine dehydrogenase, NAD-binding; In the C-terminal section; belongs to the homoserine dehydrogenase family.
 
  
 0.786
rraB
Protein of unknown function DUF1260; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
  
     0.772
Sfri_0694
PFAM: protein of unknown function DUF493; KEGG: son:SO1163 hypothetical protein; Belongs to the UPF0250 family.
  
     0.770
Sfri_0996
TPR repeat-containing protein; May be involved in cell division.
  
     0.760
Sfri_2492
PFAM: protein of unknown function DUF1414; KEGG: son:SO2176 hypothetical protein; Belongs to the UPF0352 family.
  
     0.759
Sfri_0124
PFAM: regulatory protein, TetR; KEGG: son:SO0198 transcriptional regulator, TetR family.
  
   
 0.755
Sfri_2475
PFAM: protein of unknown function DUF412; KEGG: son:SO2914 hypothetical protein.
  
     0.754
mutH
DNA mismatch repair protein MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. Belongs to the MutH family.
  
     0.750
fadR
Transcriptional regulator, GntR family; Multifunctional regulator of fatty acid metabolism.
  
   
 0.749
Your Current Organism:
Shewanella frigidimarina
NCBI taxonomy Id: 318167
Other names: S. frigidimarina NCIMB 400, Shewanella frigidimarina NCIMB 400, Shewanella frigidimarina str. NCIMB 400, Shewanella frigidimarina strain NCIMB 400
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.