Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
IO99_03425Biotin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)    
Predicted Functional Partners:
IO99_03430
ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.996
bioD
Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
  
 
 0.970
birA
biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
 
 0.948
IO99_13045
Iron-only hydrogenase system regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
    0.823
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
     
  0.811
bioA
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
  
  
 0.777
IO99_12275
NADH:ubiquinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.758
IO99_12040
Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.757
IO99_02170
2-amino-3-ketobutyrate CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.713
IO99_06375
Iron hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.586
Your Current Organism:
Clostridium sulfidigenes
NCBI taxonomy Id: 318464
Other names: C. sulfidigenes, Clostridium sulfidigenes Sallam and Steinbuchel 2009, DSM 18982, strain SGB2
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