Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
IO99_03440GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (516 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.529
gcvPB
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.
   
 
  0.519
gcvT
Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine.
  
 
  0.518
IO99_12300
Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family.
    
  0.516
IO99_14760
Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
  0.511
gcvH
Glycine cleavage system potein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
     
  0.510
gcvPA
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
     
  0.510
IO99_03360
Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
  0.510
IO99_08090
Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.486
IO99_15335
Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.436
Your Current Organism:
Clostridium sulfidigenes
NCBI taxonomy Id: 318464
Other names: C. sulfidigenes, Clostridium sulfidigenes Sallam and Steinbuchel 2009, DSM 18982, strain SGB2
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