Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
IO99_07620Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)    
Predicted Functional Partners:
IO99_15335
Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.826
IO99_01030
Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.823
proC
Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
    
  0.703
IO99_14760
Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.610
IO99_07615
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.592
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
   
  0.573
IO99_03960
acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.569
IO99_02170
2-amino-3-ketobutyrate CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.556
guaB
Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
 0.547
accD
acetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family.
    
 0.527
Your Current Organism:
Clostridium sulfidigenes
NCBI taxonomy Id: 318464
Other names: C. sulfidigenes, Clostridium sulfidigenes Sallam and Steinbuchel 2009, DSM 18982, strain SGB2
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