STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DME_LOCUS6740Poly [ADP-ribose] polymerase. (718 aa)    
Predicted Functional Partners:
DME_LOCUS7372
Uncharacterized protein.
  
 
 0.972
DME_LOCUS6114
Uncharacterized protein; Belongs to the peptidase C14A family.
    
 0.961
DME_LOCUS5826
Uncharacterized protein.
    
 
 0.943
DME_LOCUS514
Ku domain-containing protein.
   
 
 0.933
DME_LOCUS10253
Ku domain-containing protein.
   
 
 0.929
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 0.915
DME_LOCUS5416
Uncharacterized protein.
    
 0.901
DME_LOCUS8061
Uncharacterized protein.
    
 0.883
DME_LOCUS3764
Uncharacterized protein.
   
 0.882
DME_LOCUS6532
Uncharacterized protein.
   
 0.879
Your Current Organism:
Dracunculus medinensis
NCBI taxonomy Id: 318479
Other names: D. medinensis, Guinea worm, Guinea worm disease nematode, dracunculiasis worm
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.