STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DME_LOCUS8901Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (433 aa)    
Predicted Functional Partners:
DME_LOCUS9673
ATP-grasp domain-containing protein.
  
 0.999
DME_LOCUS6703
ADSL_C domain-containing protein.
  
 0.998
DME_LOCUS8722
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
  
 
 0.984
DME_LOCUS1665
GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
  
 
 0.984
DME_LOCUS7093
Uncharacterized protein.
  
 0.978
DME_LOCUS7095
MGS domain-containing protein.
  
 0.978
DME_LOCUS9845
AIRC domain-containing protein.
  
 0.975
DME_LOCUS703
Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.
  
  
 0.970
DME_LOCUS2956
Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.969
DME_LOCUS9315
PfkB domain-containing protein.
  
 0.966
Your Current Organism:
Dracunculus medinensis
NCBI taxonomy Id: 318479
Other names: D. medinensis, Guinea worm, Guinea worm disease nematode, dracunculiasis worm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.