STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
DME_LOCUS4611Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (1119 aa)    
Predicted Functional Partners:
DME_LOCUS5241
COX2_CUA domain-containing protein.
  
 0.956
DME_LOCUS7344
COX3 domain-containing protein.
  
 0.956
DME_LOCUS7345
Proton_antipo_M domain-containing protein.
   
 0.950
DME_LOCUS2114
Uncharacterized protein.
   
 0.945
DME_LOCUS3694
Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
  
 0.934
DME_LOCUS8357
Uncharacterized protein.
  
 0.927
DME_LOCUS6252
Uncharacterized protein.
  
 0.927
DME_LOCUS8029
Cytochrome c domain-containing protein.
  
 0.920
DME_LOCUS10967
Proton_antipo_M domain-containing protein.
   
 0.917
DME_LOCUS6323
Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
  
 0.916
Your Current Organism:
Dracunculus medinensis
NCBI taxonomy Id: 318479
Other names: D. medinensis, Guinea worm, Guinea worm disease nematode, dracunculiasis worm
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