Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
msrAPeptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (194 aa)    
Predicted Functional Partners:
Pden_1893
KEGG: sme:SMc00117 peptide methionine sulfoxide reductase; TIGRFAM: methionine-R-sulfoxide reductase; PFAM: Methionine sulfoxide reductase B; Belongs to the MsrB Met sulfoxide reductase family.
 
 0.994
prmA
[LSU ribosomal protein L11P]-lysine N-methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family.
       0.833
ccmG
Periplasmic protein thiol--disulfide oxidoreductase DsbE; Required for disulfide bond formation in some periplasmic proteins. Also acts as a disulfide oxidoreductase in cytochromes c biogenesis. The cysteines of apocytochromes c must be in the reduced state for covalent linkage between the two moieties to occur; Belongs to the thioredoxin family. DsbE subfamily.
   
 0.814
Pden_2023
PFAM: Redoxin domain protein; Thioredoxin domain; KEGG: rsp:RSP_0725 thioredoxin, thioldisulfide interchange protein.
   
 0.814
Pden_2586
Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
 
 
 0.715
Pden_4375
Ribonucleoside-diphosphate reductase class Ib glutaredoxin subunit; TIGRFAM: Glutaredoxin-like protein NrdH; PFAM: glutaredoxin; KEGG: sit:TM1040_0521 glutaredoxin-like protein NrdH.
  
 
 0.676
cysC
Sulfate adenylyltransferase subunit 1 / adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
   
  
 0.554
macB1
ABC transporter related protein; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
     
 0.545
Pden_3444
PFAM: ABC transporter related; protein of unknown function DUF214; SMART: AAA ATPase; KEGG: rpb:RPB_2235 hypothetical protein.
     
 0.545
Pden_0620
PFAM: peptidase S58, DmpA; KEGG: sit:TM1040_2667 peptidase S58, DmpA.
       0.539
Your Current Organism:
Paracoccus denitrificans
NCBI taxonomy Id: 318586
Other names: P. denitrificans PD1222, Paracoccus denitrificans PD1222
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