Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
fumCFumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa)    
Predicted Functional Partners:
Pden_0569
KEGG: rsp:RSP_0976 succinate dehydrogenase; TIGRFAM: succinate dehydrogenase, flavoprotein subunit; succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
 0.994
mdh
Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.988
Pden_4119
Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.975
Pden_0848
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: rsp:RSP_1217 phosphate acetyltransferase.
  
 
 0.969
Pden_2224
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))., Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: rsp:RSP_1593 phosphate acetyltransferase.
  
 
 0.969
Pden_0572
TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; KEGG: rde:RD1_1630 succinate dehydrogenase, iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 0.967
Pden_1347
KEGG: rme:Rmet_1586 2-methylcitrate synthase/citrate synthase II; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; Belongs to the citrate synthase family.
  
 0.963
Pden_3716
KEGG: sit:TM1040_1132 citrate synthase I; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family.
  
 0.963
Pden_0567
PFAM: succinate dehydrogenase, cytochrome b subunit; KEGG: rsp:RSP_0974 succinate dehydrogenase cytochrome b-556 subunit.
  
 
 0.955
Pden_3022
KEGG: rru:Rru_A1205 succinate dehydrogenase/fumarate reductase iron-sulfur protein.
  
 0.955
Your Current Organism:
Paracoccus denitrificans
NCBI taxonomy Id: 318586
Other names: P. denitrificans PD1222, Paracoccus denitrificans PD1222
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.