Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
Pden_2196PFAM: 6-phosphogluconate dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: sil:SPO0913 D-isomer specific 2-hydroxyacid dehydrogenase family protein. (316 aa)    
Predicted Functional Partners:
Pden_2195
Hydroxypyruvate reductase; PFAM: MOFRL domain protein; KEGG: sit:TM1040_3471 hydroxypyruvate reductase.
  
 0.873
Pden_2197
TIGRFAM: export-related chaperone CsaA; PFAM: t-RNA-binding domain protein; KEGG: rsp:RSP_3365 protein secretion chaperonine.
  
    0.841
proC-2
Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
  
  
 0.797
Pden_2199
KEGG: jan:Jann_3330 hypothetical protein.
       0.683
Pden_2194
PFAM: protein of unknown function DUF475; KEGG: rsp:RSP_0459 hypothetical protein.
       0.513
tal
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily.
 
  
 0.456
nnrD
Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...]
  
   0.433
Pden_2200
PFAM: aminotransferase, class I and II; KEGG: rsp:RSP_0789 aminotransferase, class-I.
       0.424
Your Current Organism:
Paracoccus denitrificans
NCBI taxonomy Id: 318586
Other names: P. denitrificans PD1222, Paracoccus denitrificans PD1222
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