STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nirDTranscriptional regulator, AsnC family; Required for the biosynthesis of heme D1 of nitrite reductase. (323 aa)    
Predicted Functional Partners:
Pden_2495
PFAM: cytochrome d1, heme region; KEGG: sil:SPOA0228 nitrite reductase protein N.
 
  
 0.989
nirC
Cytochrome c (c55X); Monoheme c-type cytochrome.
 
    0.986
Pden_2490
PFAM: cytochrome d1, heme region; KEGG: sil:SPOA0223 cytochrome cd1 nitrite reductase.
 
  
 0.983
Pden_2494
PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: sil:SPOA0227 nitrite reductase heme biosynthesis J protein.
  
 0.969
Pden_2492
Transcriptional regulator, AsnC family; KEGG: rde:RD1_1570 nitrite reductase heme biosynthesis G.
 
  
0.948
nirS
Dissimilatory nitrite reductase (NO-forming), cytochrome cd1 type apoprotein; Inactivation of this cytochrome oxidase results in the loss of nitrite and nitric oxide reductase activities, but not of nitrous oxide reductase activity.
 
  
 0.929
Pden_2493
Transcriptional regulator, AsnC family; KEGG: sil:SPOA0226 nitrite reductase heme biosynthesis H protein.
 
   
0.917
nirE
uroporphyrinogen-III C-methyltransferase; Catalyzes the methylation of both C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin (By similarity). Inactivation of uroporphyrinogen- III methyltransferase results in the loss of nitrite and nitric oxide reductase activities, but not of nitrous oxide reductase activity. Likely involved in heme D1 biosynthesis.
 
  
 0.867
Pden_2496
KEGG: rde:RD1_1575 hypothetical protein.
 
    0.821
nirI
PFAM: FMN-binding domain protein; KEGG: rde:RD1_1564 nitrous oxide reductase regulatory protein NosR.
 
    0.714
Your Current Organism:
Paracoccus denitrificans
NCBI taxonomy Id: 318586
Other names: P. denitrificans PD1222, Paracoccus denitrificans PD1222
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