Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
Pden_2986PEP phosphonomutase and related enzymes-like protein; KEGG: rpa:RPA2395 putative carboxyphosphonoenolpyruvate phosphonomutase. (163 aa)    
Predicted Functional Partners:
Pden_3071
Aconitase; PFAM: aconitate hydratase domain protein; KEGG: pol:Bpro_3871 aconitate hydratase-like.
 
 0.944
Pden_4301
Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.943
Pden_1348
2-methylcitrate dehydratase; PFAM: MmgE/PrpD family protein; KEGG: rpc:RPC_3512 2-methylcitrate dehydratase.
 
  
 0.934
Pden_1347
KEGG: rme:Rmet_1586 2-methylcitrate synthase/citrate synthase II; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; Belongs to the citrate synthase family.
 
 
 0.926
Pden_1363
PFAM: isocitrate lyase and phosphorylmutase; KEGG: ccr:CC1764 isocitrate lyase.
  
  
 0.924
sucD
succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
   
 0.914
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
   
 
 0.910
Pden_1364
KEGG: hne:HNE_1238 malate synthase A; TIGRFAM: malate synthase A; PFAM: malate synthase; Belongs to the malate synthase family.
   
 0.903
glcB
Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
   
 0.903
Pden_1346
2,3-dimethylmalate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.
  
  
 
0.901
Your Current Organism:
Paracoccus denitrificans
NCBI taxonomy Id: 318586
Other names: P. denitrificans PD1222, Paracoccus denitrificans PD1222
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