close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pden_3402Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: rfr:Rfer_3645 periplasmic sensor signal transduction histidine kinase. (467 aa)    
Predicted Functional Partners:
Pden_3403
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: rfr:Rfer_3646 two component transcriptional regulator, winged helix family.
 
 
 0.964
Pden_3891
Transketolase, central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
    
 0.888
Pden_3404
PFAM: extracellular solute-binding protein, family 1; KEGG: pub:SAR11_0769 probable binding protein component of ABC sugar transporter; TC 3.A.1.1.-.
 
     0.820
Pden_3406
Carbohydrate ABC transporter membrane protein 2, CUT1 family; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: rru:Rru_A0094 binding-protein-dependent transport systems inner membrane component; TC 3.A.1.1.-.
 
     0.714
Pden_3405
Carbohydrate ABC transporter membrane protein 1, CUT1 family; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: rru:Rru_A0093 binding-protein-dependent transport systems inner membrane component; TC 3.A.1.1.-.
 
     0.705
Pden_1604
PFAM: dehydrogenase, E1 component; Transketolase, central region; Transketolase domain protein; KEGG: sme:SMb20020 putative pyruvate dehydrogenase E1 component,alpha and beta subunits protein.
   
 0.650
Pden_3049
PFAM: dehydrogenase, E1 component; Transketolase, central region; Transketolase domain protein; KEGG: aeh:Mlg_2596 dehydrogenase, E1 component.
   
 0.650
Pden_3439
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: rpc:RPC_3029 two component transcriptional regulator, winged helix family.
 
 
 0.643
Pden_3312
Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: ret:RHE_PF00324 probable two-component sensor histidine kinase/response regulator hybrid protein.
 
 
 0.636
Pden_3566
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: bja:blr6651 two-component response regulator.
 
 
 0.627
Your Current Organism:
Paracoccus denitrificans
NCBI taxonomy Id: 318586
Other names: P. denitrificans PD1222, Paracoccus denitrificans PD1222
Server load: low (26%) [HD]