Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
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[Homology]
Score
hisD-3Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (436 aa)    
Predicted Functional Partners:
hisB
PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: rsp:RSP_2246 imidazoleglycerol-phosphate dehydratase.
  
 0.955
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
 0.940
hisH
Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.927
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.907
hisA
1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: jan:Jann_2792 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
 
  
 0.899
Pden_1336
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family.
 
  
 0.898
Pden_3580
PFAM: short-chain dehydrogenase/reductase SDR; KR; KEGG: bxe:Bxe_C0308 putative short-chain dehydrogenase/reductase.
 
 
   0.850
hisE
PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: sil:SPO1155 phosphoribosyl-ATP pyrophosphatase.
 
  
 0.845
hisC
TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class V; aminotransferase, class I and II; KEGG: rsp:RSP_2284 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
 0.840
Pden_0652
PFAM: aminotransferase, class I and II; KEGG: sil:SPO3027 aminotransferase, classes I and II.
  
 0.834
Your Current Organism:
Paracoccus denitrificans
NCBI taxonomy Id: 318586
Other names: P. denitrificans PD1222, Paracoccus denitrificans PD1222
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