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query proteins and first shell of interactors
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second shell of interactors
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Pden_4380Putative transcriptional regulator, GntR family; PFAM: aminotransferase, class I and II; KEGG: xcv:XCV1904 putative aminotransferase. (415 aa)    
Predicted Functional Partners:
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
   
 
 0.908
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.906
Pden_0729
PFAM: aminotransferase, class V; KEGG: rsp:RSP_0245 serine-pyruvate aminotransferase/aspartate aminotransferase.
  
 
 0.905
Pden_1941
Glyoxylate reductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: jan:Jann_0915 glycolate reductase.
  
 
  0.905
bhcA
Serine-glyoxylate aminotransferase apoenzyme; Catalyzes the transamination of glyoxylate into glycine using L-aspartate as the preferred amino group donor. Is essential for the growth of P.denitrificans in the presence of glycolate and glyoxylate since it functions in glyoxylate assimilation via the beta- hydroxyaspartate cycle (BHAC). Can catalyze the reverse reaction in vitro, and also use L-serine and L-glutamate as amino group donor, but with much less efficiency than L-aspartate.
  
 
 0.905
Pden_2348
TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: rsp:RSP_2193 predicted aminomethyltransferase, tetrahydrofolate dependent.
  
 
  0.904
Pden_1397
PFAM: glutamine synthetase, catalytic region; KEGG: rsp:RSP_0377 probable glutamine synthetase.
    
 0.902
Pden_3702
Glutamate--putrescine ligase; PFAM: glutamine synthetase, catalytic region; KEGG: rsp:RSP_0375 probable glutamine synthetase.
    
 0.902
bhcC
D-3-hydroxyaspartate aldolase; Catalyzes the condensation of glyoxylate and glycine into (2R,3S)-beta-hydroxyaspartate ((3S)-3-hydroxy-D-aspartate). Is essential for the growth of P.denitrificans in the presence of glycolate and glyoxylate since it functions in glyoxylate assimilation via the beta-hydroxyaspartate cycle (BHAC). Is also able to catalyze the reverse reaction in vitro, i.e. the cleavage of (3S)-3-hydroxy-D- aspartate, and that of D-threonine to a lesser extent. Belongs to the DSD1 family.
   
 
  0.902
Pden_4037
PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: jan:Jann_3650 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding.
    
  0.902
Your Current Organism:
Paracoccus denitrificans
NCBI taxonomy Id: 318586
Other names: P. denitrificans PD1222, Paracoccus denitrificans PD1222
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