STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Plut_1526Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (385 aa)    
Predicted Functional Partners:
Plut_1617
Pyruvate:ferredoxin (flavodoxin) oxidoreductase.
  
 
 0.945
Plut_0599
2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
  
 
0.924
leuA-2
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
  
 
0.922
Plut_1072
2-oxoacid:ferredoxin oxidoreductase, alpha subunit.
  
 
 0.919
Plut_1954
2-oxoglutarate ferredoxin oxidoreductase, alpha subunit.
  
 
 0.919
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.912
Plut_1073
2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate.
   
 
 0.904
Plut_1955
2-oxoglutarate ferredoxin oxidoreductase, beta subunit.
   
 
 0.904
Plut_1074
Phosphate butyryltransferase.
     
 0.903
Plut_1960
Acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 
  0.903
Your Current Organism:
Pelodictyon luteolum
NCBI taxonomy Id: 319225
Other names: Chlorobium luteolum DSM 273, Chlorobium luteolum str. DSM 273, Chlorobium luteolum strain DSM 273, P. luteolum DSM 273, Pelodictyon luteolum DSM 273
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.