ANN14245.1 protein (Amycolatopsis orientalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ANN14245.1

PE-PGRS family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1088 aa)

Predicted Functional Partners:

ANN20526.1

0.746

ANN22212.1

0.715

ANN21477.1

0.710

ANN21235.1

0.677

ANN18529.1

0.674

ANN16416.1

0.670

ANN14219.1

0.653

ANN19609.1

0.646

ANN20993.1

0.630

ANN20841.1

0.625

Your Current Organism:

Amycolatopsis orientalis

NCBI taxonomy Id: 31958
Other names: A. orientalis, ATCC 19795, Actinoplanes sp. ATCC 53771, Amycolatopsis orientalis orientalis, Amycolatopsis orientalis subsp. orientalis, CIP 107113, DSM 40040, IFO 12806, IMSNU 20058, ISP 5040, JCM 4235, JCM 4600, KCTC 9412, NBRC 12806, NRRL 2450, Nocardia orientalis, Streptomyces orientalis, UNIQEM 181, VKM Ac-866

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANN14219.1	ANN14245.1	SD37_00145	SD37_00300	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	PE-PGRS family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.653
ANN14219.1	ANN20993.1	SD37_00145	SD37_39025	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.400
ANN14245.1	ANN14219.1	SD37_00300	SD37_00145	PE-PGRS family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.653
ANN14245.1	ANN16416.1	SD37_00300	SD37_12645	PE-PGRS family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	GCN5 family acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.670
ANN14245.1	ANN18529.1	SD37_00300	SD37_24800	PE-PGRS family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.674
ANN14245.1	ANN19609.1	SD37_00300	SD37_31005	PE-PGRS family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Alpha/beta hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.646
ANN14245.1	ANN20526.1	SD37_00300	SD37_36355	PE-PGRS family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.746
ANN14245.1	ANN20841.1	SD37_00300	SD37_38130	PE-PGRS family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.625
ANN14245.1	ANN20993.1	SD37_00300	SD37_39025	PE-PGRS family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.630
ANN14245.1	ANN21235.1	SD37_00300	SD37_40435	PE-PGRS family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.677
ANN14245.1	ANN21477.1	SD37_00300	SD37_00760	PE-PGRS family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sterol-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.710
ANN14245.1	ANN22212.1	SD37_00300	SD37_33825	PE-PGRS family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.715
ANN16416.1	ANN14245.1	SD37_12645	SD37_00300	GCN5 family acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	PE-PGRS family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.670
ANN18529.1	ANN14245.1	SD37_24800	SD37_00300	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	PE-PGRS family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.674
ANN18529.1	ANN20526.1	SD37_24800	SD37_36355	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.636
ANN18529.1	ANN20841.1	SD37_24800	SD37_38130	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.476
ANN18529.1	ANN20993.1	SD37_24800	SD37_39025	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.441
ANN19609.1	ANN14245.1	SD37_31005	SD37_00300	Alpha/beta hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	PE-PGRS family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.646
ANN19609.1	ANN21477.1	SD37_31005	SD37_00760	Alpha/beta hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sterol-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.409
ANN19609.1	ANN22212.1	SD37_31005	SD37_33825	Alpha/beta hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.512

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.92

expected number of edges:

15

PPI enrichment p-value:

0.000757

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009451

RNA modification

9 of 93

1.77

3.9

3.77e-12

GO:0001510

RNA methylation

6 of 40

1.96

3.39

1.69e-08

GO:0030488

tRNA methylation

5 of 21

2.16

3.37

1.04e-07

GO:0006400

tRNA modification

7 of 65

1.82

3.35

2.75e-09

GO:0034470

ncRNA processing

11 of 286

1.37

2.45

3.77e-12

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008173

RNA methyltransferase activity

5 of 35

1.94

2.74

9.20e-07

GO:0008175

tRNA methyltransferase activity

4 of 15

2.21

2.74

3.51e-06

GO:0140101

Catalytic activity, acting on a tRNA

6 of 82

1.65

2.34

8.80e-07

GO:0016423

tRNA (guanine) methyltransferase activity

3 of 7

2.42

2.28

5.00e-05

GO:0008757

S-adenosylmethionine-dependent methyltransferase activity

5 of 71

1.63

1.99

1.26e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043527

tRNA methyltransferase complex

2 of 6

2.31

0.93

0.0196

GO:0005730

Nucleolus

5 of 267

1.06

0.65

0.0172

GO:0005634

Nucleus

11 of 2141

0.5

0.39

0.0031

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3040

rRNA processing, and tRNA methylation

10 of 173

1.55

3.12

2.05e-12

CL:3361

tRNA methylation

4 of 10

2.39

3.03

1.39e-06

CL:3045

rRNA processing, and Ribosomal large subunit biogenesis

6 of 151

1.38

1.62

1.68e-05

CL:3363

tRNA methyltransferase complex

2 of 5

2.39

1.2

0.0061

CL:3334

Box H/ACA RNP complex, and Gar1/Naf1 RNA binding region

2 of 6

2.31

1.18

0.0065

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03008

Ribosome biogenesis in eukaryotes

3 of 76

1.38

0.68

0.0341

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8953854

Metabolism of RNA

8 of 503

0.99

0.94

0.00013

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031429

Box H/ACA snoRNP complex

2 of 5

2.39

0.73

0.0472

GOCC:0043527

tRNA methyltransferase complex

2 of 6

2.31

0.72

0.0472

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0949

S-adenosyl-L-methionine

5 of 35

1.94

2.82

5.82e-07

KW-0489

Methyltransferase

5 of 73

1.62

2.02

9.08e-06

KW-0694

RNA-binding

5 of 112

1.43

1.59

4.66e-05

KW-0820

tRNA-binding

2 of 9

2.13

1.13

0.0074

KW-0819

tRNA processing

2 of 20

1.78

0.83

0.0247

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16198

tRNA pseudouridylate synthase B C-terminal domain

2 of 2

2.78

1.08

0.0109

PF01509

TruB family pseudouridylate synthase (N terminal domain)

2 of 2

2.78

1.08

0.0109

PF01189

16S rRNA methyltransferase RsmB/F

2 of 3

2.61

1.08

0.0109

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029063

S-adenosyl-L-methionine-dependent methyltransferase superfamily

6 of 74

1.69

2.29

2.34e-06

IPR020103

Pseudouridine synthase, catalytic domain superfamily

3 of 7

2.42

1.8

0.00044

IPR032819

tRNA pseudouridylate synthase B, C-terminal

2 of 2

2.78

1.08

0.0109

IPR023267

RNA (C5-cytosine) methyltransferase

2 of 3

2.61

1.08

0.0109

IPR018314

Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site

2 of 2

2.78

1.08

0.0109

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Textmining

Coexpression

Databases

Fusion

© STRING Consortium 2024

Credits

Access

Info

About