ANN14323.1 protein (Amycolatopsis orientalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ANN14323.1

ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)

Predicted Functional Partners:

ANN14322.1

0.958

ANN14729.1

0.825

ANN18387.1

0.825

ANN18741.1

0.821

ANN22214.1

0.820

ANN17323.1

0.809

ANN15122.1

0.784

ANN18845.1

0.784

ANN16919.1

0.783

ANN15168.1

0.756

Your Current Organism:

Amycolatopsis orientalis

NCBI taxonomy Id: 31958
Other names: A. orientalis, ATCC 19795, Actinoplanes sp. ATCC 53771, Amycolatopsis orientalis orientalis, Amycolatopsis orientalis subsp. orientalis, CIP 107113, DSM 40040, IFO 12806, IMSNU 20058, ISP 5040, JCM 4235, JCM 4600, KCTC 9412, NBRC 12806, NRRL 2450, Nocardia orientalis, Streptomyces orientalis, UNIQEM 181, VKM Ac-866

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANN14322.1	ANN14323.1	SD37_00725	SD37_00730	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.958
ANN14322.1	ANN14729.1	SD37_00725	SD37_03035	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.486
ANN14322.1	ANN15122.1	SD37_00725	SD37_05235	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.500
ANN14322.1	ANN15168.1	SD37_00725	SD37_05510	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.523
ANN14322.1	ANN16919.1	SD37_00725	SD37_15540	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.507
ANN14322.1	ANN17323.1	SD37_00725	SD37_17840	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.709
ANN14322.1	ANN18387.1	SD37_00725	SD37_23965	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.520
ANN14322.1	ANN18741.1	SD37_00725	SD37_26035	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.719
ANN14322.1	ANN18845.1	SD37_00725	SD37_26615	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.513
ANN14322.1	ANN22214.1	SD37_00725	SD37_33840	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.719
ANN14323.1	ANN14322.1	SD37_00730	SD37_00725	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.958
ANN14323.1	ANN14729.1	SD37_00730	SD37_03035	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.825
ANN14323.1	ANN15122.1	SD37_00730	SD37_05235	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.784
ANN14323.1	ANN15168.1	SD37_00730	SD37_05510	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.756
ANN14323.1	ANN16919.1	SD37_00730	SD37_15540	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.783
ANN14323.1	ANN17323.1	SD37_00730	SD37_17840	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.809
ANN14323.1	ANN18387.1	SD37_00730	SD37_23965	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.825
ANN14323.1	ANN18741.1	SD37_00730	SD37_26035	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.821
ANN14323.1	ANN18845.1	SD37_00730	SD37_26615	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.784
ANN14323.1	ANN22214.1	SD37_00730	SD37_33840	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.820

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Network Stats

number of nodes:

11

number of edges:

13

average node degree:

2.36

avg. local clustering coefficient:

0.885

expected number of edges:

10

PPI enrichment p-value:

0.233

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046907

Intracellular transport

5 of 521

1.35

0.95

0.0054

GO:0006886

Intracellular protein transport

4 of 319

1.46

0.92

0.0092

GO:0015031

Protein transport

5 of 823

1.15

0.74

0.0124

GO:0006606

Protein import into nucleus

2 of 40

2.06

0.74

0.0427

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043227

Membrane-bounded organelle

11 of 7441

0.54

0.43

0.0011

GO:0043229

Intracellular organelle

11 of 7650

0.52

0.42

0.0011

GO:0005737

Cytoplasm

10 of 6797

0.53

0.41

0.0031

GO:0043231

Intracellular membrane-bounded organelle

10 of 6999

0.52

0.4

0.0033

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3521

LAG1, DNA binding, and Protein of unknown function DUF6699

2 of 5

2.97

1.61

0.0012

CL:2008

Mixed, incl. Exportin-1/5, and Zinc finger, RanBP2-type

2 of 5

2.97

1.61

0.0012

CL:1954

Nuclear pore

3 of 32

2.34

1.58

0.0011

CL:15982

Mostly uncharacterized, incl. Serine-type endopeptidase activity, and Multifunctional anion exchangers

3 of 145

1.68

1.17

0.0035

CL:16106

Mixed, incl. Multifunctional anion exchangers, and Tyrosine/serine-protein phosphatase IphP-type

2 of 34

2.14

1.1

0.0085

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-68875

Mitotic Prophase

3 of 53

2.12

1.62

0.00076

MAP-68886

M Phase

4 of 175

1.72

1.47

0.00070

MAP-2980766

Nuclear Envelope Breakdown

2 of 26

2.25

0.92

0.0198

MAP-69278

Cell Cycle, Mitotic

4 of 630

1.17

0.66

0.0253

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR040159

Suppressor of hairless-like

2 of 2

3.37

1.39

0.0032

IPR037095

RBP-J/Cbf11, DNA binding domain superfamily

2 of 2

3.37

1.39

0.0032

IPR036358

Beta-trefoil domain superfamily

2 of 2

3.37

1.39

0.0032

IPR015351

RBP-J/Cbf11/Cbf12, DNA binding

2 of 2

3.37

1.39

0.0032

IPR015350

Beta-trefoil DNA-binding domain

2 of 2

3.37

1.39

0.0032

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01268

Beta-trefoil DNA-binding domain

2 of 2

3.37

1.93

0.00034

SM01267

LAG1, DNA binding

2 of 2

3.37

1.93

0.00034

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