ANN16526.1 protein (Amycolatopsis orientalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

ANN16526.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)

Predicted Functional Partners:

ANN16527.1

0.762

ANN21739.1

0.535

ANN16525.1

0.523

ANN16528.1

0.476

Your Current Organism:

Amycolatopsis orientalis

NCBI taxonomy Id: 31958
Other names: A. orientalis, ATCC 19795, Actinoplanes sp. ATCC 53771, Amycolatopsis orientalis orientalis, Amycolatopsis orientalis subsp. orientalis, CIP 107113, DSM 40040, IFO 12806, IMSNU 20058, ISP 5040, JCM 4235, JCM 4600, KCTC 9412, NBRC 12806, NRRL 2450, Nocardia orientalis, Streptomyces orientalis, UNIQEM 181, VKM Ac-866

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANN16525.1	ANN16526.1	SD37_13250	SD37_13255	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.523
ANN16525.1	ANN16527.1	SD37_13250	SD37_13260	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.516
ANN16526.1	ANN16525.1	SD37_13255	SD37_13250	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.523
ANN16526.1	ANN16527.1	SD37_13255	SD37_13260	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.762
ANN16526.1	ANN16528.1	SD37_13255	SD37_13270	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carnitine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CoA-transferase III family.	0.476
ANN16526.1	ANN21739.1	SD37_13255	SD37_13265	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.535
ANN16527.1	ANN16525.1	SD37_13260	SD37_13250	TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.516
ANN16527.1	ANN16526.1	SD37_13260	SD37_13255	TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.762
ANN16527.1	ANN16528.1	SD37_13260	SD37_13270	TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carnitine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CoA-transferase III family.	0.483
ANN16527.1	ANN21739.1	SD37_13260	SD37_13265	TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.543
ANN16528.1	ANN16526.1	SD37_13270	SD37_13255	Carnitine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CoA-transferase III family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.476
ANN16528.1	ANN16527.1	SD37_13270	SD37_13260	Carnitine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CoA-transferase III family.	TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.483
ANN16528.1	ANN21739.1	SD37_13270	SD37_13265	Carnitine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CoA-transferase III family.	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.799
ANN21739.1	ANN16526.1	SD37_13265	SD37_13255	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.535
ANN21739.1	ANN16527.1	SD37_13265	SD37_13260	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.543
ANN21739.1	ANN16528.1	SD37_13265	SD37_13270	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carnitine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CoA-transferase III family.	0.799

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

15

PPI enrichment p-value:

1.55e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006098

Pentose-phosphate shunt

4 of 11

1.93

0.00010

GO:0046365

Monosaccharide catabolic process

4 of 18

1.71

1.7

0.00017

GO:0005996

Monosaccharide metabolic process

5 of 39

1.47

1.55

0.00010

GO:0019323

Pentose catabolic process

3 of 8

1.94

1.49

0.0011

GO:0044282

Small molecule catabolic process

6 of 60

1.37

1.43

0.00010

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:877

NADPH regeneration, and Gluconate transporter

6 of 8

2.24

4.18

1.95e-09

CL:757

Carbon metabolism, and Pyruvate metabolism

7 of 68

1.38

1.83

1.16e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

thl00040

Pentose and glucuronate interconversions

4 of 12

1.89

2.31

9.85e-06

thl00030

Pentose phosphate pathway

5 of 27

1.63

2.12

4.35e-06

thl01120

Microbial metabolism in diverse environments

8 of 123

1.18

1.49

4.94e-07

thl01200

Carbon metabolism

5 of 65

1.25

1.27

0.00012

thl00480

Glutathione metabolism

2 of 8

1.76

1.01

0.0096

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005856

Cytoskeleton

3 of 20

1.54

0.79

0.0236

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036409

Class II aldolase/adducin N-terminal domain superfamily

3 of 3

2.37

1.57

0.0012

IPR001303

Class II aldolase/adducin N-terminal

3 of 3

2.37

1.57

0.0012

IPR006183

6-phosphogluconate dehydrogenase

2 of 2

2.37

0.79

0.0354

IPR006114

6-phosphogluconate dehydrogenase, C-terminal

2 of 2

2.37

0.79

0.0354

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01007

Class II Aldolase and Adducin N-terminal domain

3 of 3

2.37

2.07

0.00012

SM01350

6-phosphogluconate dehydrogenase, C-terminal domain

2 of 2

2.37

1.23

0.0052

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