ANN21931.1 protein (Amycolatopsis orientalis)

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ANN21931.1

Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)

Predicted Functional Partners:

ANN18022.1

0.995

ANN18023.1

0.965

ANN15673.1

0.852

ANN17820.1

0.849

ANN21974.1

0.845

ANN17842.1

0.843

ANN15945.1

0.842

ANN18724.1

0.842

ANN17331.1

0.841

ANN15671.1

0.840

Your Current Organism:

Amycolatopsis orientalis

NCBI taxonomy Id: 31958
Other names: A. orientalis, ATCC 19795, Actinoplanes sp. ATCC 53771, Amycolatopsis orientalis orientalis, Amycolatopsis orientalis subsp. orientalis, CIP 107113, DSM 40040, IFO 12806, IMSNU 20058, ISP 5040, JCM 4235, JCM 4600, KCTC 9412, NBRC 12806, NRRL 2450, Nocardia orientalis, Streptomyces orientalis, UNIQEM 181, VKM Ac-866

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANN15671.1	ANN15673.1	SD37_08370	SD37_08380	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
ANN15671.1	ANN15945.1	SD37_08370	SD37_10025	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.588
ANN15671.1	ANN17331.1	SD37_08370	SD37_17885	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.592
ANN15671.1	ANN17820.1	SD37_08370	SD37_20655	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.646
ANN15671.1	ANN17842.1	SD37_08370	SD37_20775	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thiamine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.581
ANN15671.1	ANN18023.1	SD37_08370	SD37_21800	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.849
ANN15671.1	ANN18724.1	SD37_08370	SD37_25925	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.585
ANN15671.1	ANN21931.1	SD37_08370	SD37_21805	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.840
ANN15671.1	ANN21974.1	SD37_08370	SD37_23515	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.468
ANN15673.1	ANN15671.1	SD37_08380	SD37_08370	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
ANN15673.1	ANN18022.1	SD37_08380	SD37_21795	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.826
ANN15673.1	ANN21931.1	SD37_08380	SD37_21805	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.852
ANN15945.1	ANN15671.1	SD37_10025	SD37_08370	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.588
ANN15945.1	ANN18022.1	SD37_10025	SD37_21795	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.494
ANN15945.1	ANN21931.1	SD37_10025	SD37_21805	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.842
ANN17331.1	ANN15671.1	SD37_17885	SD37_08370	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.592
ANN17331.1	ANN18022.1	SD37_17885	SD37_21795	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.507
ANN17331.1	ANN21931.1	SD37_17885	SD37_21805	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.841
ANN17820.1	ANN15671.1	SD37_20655	SD37_08370	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.646
ANN17820.1	ANN18022.1	SD37_20655	SD37_21795	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.560

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

26

PPI enrichment p-value:

3.38e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006366

Transcription by RNA polymerase II

10 of 85

2.23

7.43

1.30e-18

GO:0001172

Transcription, RNA-templated

4 of 9

2.81

4.1

2.31e-08

GO:0098781

ncRNA transcription

4 of 14

2.62

3.74

8.55e-08

GO:0006360

Transcription by RNA polymerase I

4 of 20

2.46

3.46

2.12e-07

GO:0006383

Transcription by RNA polymerase III

4 of 21

2.44

3.43

2.30e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

7 of 24

2.63

6.87

2.51e-14

GO:0031369

Translation initiation factor binding

2 of 9

2.51

1.41

0.0026

GO:0003677

DNA binding

8 of 860

1.13

1.33

2.30e-06

GO:0003676

Nucleic acid binding

9 of 1578

0.92

0.94

7.20e-06

GO:1901363

Heterocyclic compound binding

10 of 3180

0.66

0.57

0.00014

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005665

RNA polymerase II, core complex

10 of 12

3.08

13.41

1.95e-26

GO:0005736

RNA polymerase I complex

4 of 12

2.68

4.21

1.11e-08

GO:0005666

RNA polymerase III complex

4 of 18

2.51

3.83

4.20e-08

GO:0005730

Nucleolus

5 of 273

1.42

1.64

2.40e-05

GO:0000932

P-body

2 of 30

1.98

1.14

0.0065

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7704

RNA polymerase II, core complex

9 of 10

3.12

11.75

5.86e-23

CL:7706

RNA polymerase II, core complex

5 of 5

3.16

6.39

1.79e-12

CL:7670

Mixed, incl. RNA Polymerase II Pre-transcription Events, and RNA Polymerase III Transcription

11 of 178

1.95

6.21

1.71e-19

CL:7673

Mixed, incl. RNA Polymerase II Pre-transcription Events, and Tyrosinase activity

10 of 143

2.01

6.13

8.72e-18

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

10 of 40

2.56

10.33

5.92e-23

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9018519

Estrogen-dependent gene expression

10 of 32

2.66

10.71

5.20e-23

MAP-77075

RNA Pol II CTD phosphorylation and interaction with CE

10 of 35

2.62

10.56

5.64e-23

MAP-72086

mRNA Capping

10 of 37

2.59

10.45

6.10e-23

MAP-113418

Formation of the Early Elongation Complex

10 of 39

2.57

10.34

7.26e-23

MAP-8939211

ESR-mediated signaling

10 of 43

2.53

10.06

1.38e-22

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

8 of 81

2.16

5.58

1.06e-13

GOCC:0005665

RNA polymerase II, core complex

4 of 4

3.16

4.76

2.03e-09

GOCC:0055029

Nuclear DNA-directed RNA polymerase complex

5 of 59

2.09

3.37

6.38e-08

GOCC:0005736

RNA polymerase I complex

2 of 5

2.76

1.68

0.00086

GOCC:0031981

Nuclear lumen

5 of 561

1.11

0.9

0.0018

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036603

RNA polymerase, RBP11-like subunit

2 of 4

2.86

0.96

0.0186

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