ANN19330.1 protein (Amycolatopsis orientalis)

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Known Interactions

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experimentally determined

Predicted Interactions

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Score

ANN19330.1

Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (352 aa)

Predicted Functional Partners:

ANN19331.1

0.596

ANN19332.1

0.550

ANN19333.1

0.550

ANN19334.1

0.550

ANN15741.1

0.448

ANN20247.1

0.433

Your Current Organism:

Amycolatopsis orientalis

NCBI taxonomy Id: 31958
Other names: A. orientalis, ATCC 19795, Actinoplanes sp. ATCC 53771, Amycolatopsis orientalis orientalis, Amycolatopsis orientalis subsp. orientalis, CIP 107113, DSM 40040, IFO 12806, IMSNU 20058, ISP 5040, JCM 4235, JCM 4600, KCTC 9412, NBRC 12806, NRRL 2450, Nocardia orientalis, Streptomyces orientalis, UNIQEM 181, VKM Ac-866

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANN15741.1	ANN19330.1	SD37_08780	SD37_29425	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.448
ANN19330.1	ANN15741.1	SD37_29425	SD37_08780	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.448
ANN19330.1	ANN19331.1	SD37_29425	SD37_29430	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.596
ANN19330.1	ANN19332.1	SD37_29425	SD37_29435	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.550
ANN19330.1	ANN19333.1	SD37_29425	SD37_29440	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.550
ANN19330.1	ANN19334.1	SD37_29425	SD37_29445	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.550
ANN19330.1	ANN20247.1	SD37_29425	SD37_34730	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADPH-dependent FMN reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.433
ANN19331.1	ANN19330.1	SD37_29430	SD37_29425	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.596
ANN19331.1	ANN19332.1	SD37_29430	SD37_29435	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.952
ANN19331.1	ANN19333.1	SD37_29430	SD37_29440	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.939
ANN19331.1	ANN19334.1	SD37_29430	SD37_29445	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.837
ANN19332.1	ANN19330.1	SD37_29435	SD37_29425	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.550
ANN19332.1	ANN19331.1	SD37_29435	SD37_29430	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.952
ANN19332.1	ANN19333.1	SD37_29435	SD37_29440	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.978
ANN19332.1	ANN19334.1	SD37_29435	SD37_29445	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
ANN19333.1	ANN19330.1	SD37_29440	SD37_29425	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.550
ANN19333.1	ANN19331.1	SD37_29440	SD37_29430	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.939
ANN19333.1	ANN19332.1	SD37_29440	SD37_29435	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.978
ANN19333.1	ANN19334.1	SD37_29440	SD37_29445	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
ANN19334.1	ANN19330.1	SD37_29445	SD37_29425	Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.550

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.808

expected number of edges:

11

PPI enrichment p-value:

2.41e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000154

rRNA modification

5 of 40

2.18

3.4

9.48e-08

GO:0006364

rRNA processing

9 of 321

1.53

2.71

6.96e-10

GO:0031167

rRNA methylation

4 of 31

2.19

2.68

4.51e-06

GO:0009451

RNA modification

6 of 166

1.64

2.34

7.76e-07

GO:0000494

Box C/D RNA 3-end processing

2 of 3

2.91

1.61

0.0012

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009383

rRNA (cytosine-C5-)-methyltransferase activity

2 of 3

2.91

1.48

0.0021

GO:0008649

rRNA methyltransferase activity

3 of 30

2.08

1.46

0.0015

GO:0030515

snoRNA binding

3 of 33

2.04

1.45

0.0015

GO:0003723

RNA binding

9 of 870

1.1

1.27

2.24e-06

GO:0003676

Nucleic acid binding

10 of 1881

0.81

0.76

3.15e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031428

Box C/D RNP complex

4 of 9

2.73

4.09

2.10e-08

GO:0005730

Nucleolus

11 of 388

1.53

3.32

1.44e-14

GO:0030684

Preribosome

6 of 138

1.72

2.77

6.63e-08

GO:0032040

Small-subunit processome

4 of 70

1.84

2.11

2.40e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8147

Preribosome, large subunit precursor, and Nop2p

4 of 31

2.19

2.29

3.21e-05

CL:7981

Small-subunit processome

3 of 18

2.3

2.06

0.00012

CL:7917

Small-subunit processome, and Protein AATF/Bfr2

4 of 54

1.95

2.03

6.44e-05

CL:8149

Preribosome, large subunit precursor, and Nop2p

3 of 20

2.26

2.01

0.00014

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03008

Ribosome biogenesis in eukaryotes

6 of 138

1.72

2.72

1.01e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8868773

rRNA processing in the nucleus and cytosol

5 of 213

1.45

1.34

0.00047

MAP-72312

rRNA processing

5 of 221

1.44

1.33

0.00047

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

4 of 206

1.37

0.99

0.0045

MAP-8953854

Metabolism of RNA

7 of 853

1.0

0.88

0.00047

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031428

Box C/D snoRNP complex

4 of 6

2.91

4.07

3.06e-08

GOCC:0005732

Small nucleolar ribonucleoprotein complex

5 of 24

2.4

3.93

1.81e-08

GOCC:0005730

Nucleolus

6 of 176

1.61

2.26

1.02e-06

GOCC:0016363

Nuclear matrix

2 of 10

2.38

1.26

0.0047

GOCC:0031981

Nuclear lumen

8 of 799

1.08

1.2

7.18e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0489

Methyltransferase

3 of 68

1.73

1.14

0.0047

KW-0808

Transferase

5 of 454

1.12

0.83

0.0047

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF17125

N-terminal domain of 16S rRNA methyltransferase RsmF

2 of 2

3.08

1.19

0.0071

PF08156

NOP5NT (NUC127) domain

2 of 2

3.08

1.19

0.0071

PF01189

16S rRNA methyltransferase RsmB/F

2 of 4

2.78

1.19

0.0071

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045056

Nucleolar protein Nop56/Nop58

2 of 2

3.08

0.96

0.0186

IPR042239

Nop, C-terminal domain

2 of 3

2.91

0.96

0.0186

IPR036070

Nop domain superfamily

2 of 3

2.91

0.96

0.0186

IPR031341

Ribosomal RNA small subunit methyltransferase F, N-terminal

2 of 2

3.08

0.96

0.0186

IPR023273

RNA (C5-cytosine) methyltransferase, NOP2

2 of 2

3.08

0.96

0.0186

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00931

NOSIC (NUC001) domain

2 of 3

2.91

1.43

0.0026

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