node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CMS0596 | folD | CMS0596 | CMS0585 | Putative formyltetrahydrofolate deformylase. | Putative methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.973 |
CMS0596 | fumC | CMS0596 | CMS2420 | Putative formyltetrahydrofolate deformylase. | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.804 |
CMS0596 | gcvT | CMS0596 | CMS2224 | Putative formyltetrahydrofolate deformylase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.926 |
CMS0596 | glyA | CMS0596 | CMS0586 | Putative formyltetrahydrofolate deformylase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.958 |
CMS0596 | mqo | CMS0596 | CMS0162 | Putative formyltetrahydrofolate deformylase. | Probable malate:quinone oxidoreductase. | 0.816 |
CMS0596 | pckG | CMS0596 | CMS1507 | Putative formyltetrahydrofolate deformylase. | Putative phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. | 0.800 |
CMS0596 | purH | CMS0596 | CMS2592 | Putative formyltetrahydrofolate deformylase. | Bifunctional purine biosynthesis protein. | 0.815 |
CMS0596 | purN | CMS0596 | CMS2593 | Putative formyltetrahydrofolate deformylase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.926 |
CMS0596 | pyc | CMS0596 | CMS1351 | Putative formyltetrahydrofolate deformylase. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.800 |
CMS0596 | thyX | CMS0596 | CMS1197 | Putative formyltetrahydrofolate deformylase. | Conserved hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.900 |
folD | CMS0596 | CMS0585 | CMS0596 | Putative methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative formyltetrahydrofolate deformylase. | 0.973 |
folD | gcvT | CMS0585 | CMS2224 | Putative methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.947 |
folD | glyA | CMS0585 | CMS0586 | Putative methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.997 |
folD | purH | CMS0585 | CMS2592 | Putative methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Bifunctional purine biosynthesis protein. | 0.969 |
folD | purN | CMS0585 | CMS2593 | Putative methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.974 |
folD | thyX | CMS0585 | CMS1197 | Putative methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Conserved hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.913 |
fumC | CMS0596 | CMS2420 | CMS0596 | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Putative formyltetrahydrofolate deformylase. | 0.804 |
fumC | mqo | CMS2420 | CMS0162 | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Probable malate:quinone oxidoreductase. | 0.969 |
gcvT | CMS0596 | CMS2224 | CMS0596 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Putative formyltetrahydrofolate deformylase. | 0.926 |
gcvT | folD | CMS2224 | CMS0585 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Putative methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.947 |