| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CMS0352 | CMS1179 | CMS0352 | CMS1179 | Putative methyltransferase. | Conserved hypothetical protein. | 0.920 |
| CMS0352 | metK | CMS0352 | CMS2024 | Putative methyltransferase. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.964 |
| CMS0352 | mmuM | CMS0352 | CMS2974 | Putative methyltransferase. | Homocysteine s-methyltransferase. | 0.916 |
| CMS1179 | CMS0352 | CMS1179 | CMS0352 | Conserved hypothetical protein. | Putative methyltransferase. | 0.920 |
| CMS1179 | metK | CMS1179 | CMS2024 | Conserved hypothetical protein. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.964 |
| CMS1179 | mmuM | CMS1179 | CMS2974 | Conserved hypothetical protein. | Homocysteine s-methyltransferase. | 0.916 |
| coaBC | gmk | CMS2025 | CMS2027 | Coenzyme A biosynthesis bifunctional protein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.781 |
| coaBC | metK | CMS2025 | CMS2024 | Coenzyme A biosynthesis bifunctional protein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.929 |
| coaBC | rpe | CMS2025 | CMS2020 | Coenzyme A biosynthesis bifunctional protein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2; Belongs to the ribulose-phosphate 3-epimerase family. | 0.462 |
| gmk | coaBC | CMS2027 | CMS2025 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Coenzyme A biosynthesis bifunctional protein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.781 |
| gmk | guaA | CMS2027 | CMS0540 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.977 |
| gmk | metK | CMS2027 | CMS2024 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.810 |
| gmk | rpe | CMS2027 | CMS2020 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2; Belongs to the ribulose-phosphate 3-epimerase family. | 0.563 |
| guaA | gmk | CMS0540 | CMS2027 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.977 |
| guaA | metK | CMS0540 | CMS2024 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.747 |
| guaA | purF | CMS0540 | CMS1031 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.793 |
| metK | CMS0352 | CMS2024 | CMS0352 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Putative methyltransferase. | 0.964 |
| metK | CMS1179 | CMS2024 | CMS1179 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Conserved hypothetical protein. | 0.964 |
| metK | coaBC | CMS2024 | CMS2025 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Coenzyme A biosynthesis bifunctional protein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.929 |
| metK | gmk | CMS2024 | CMS2027 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.810 |