STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
KRN66974.1Major facilitator superfamily protein. (491 aa)    
Predicted Functional Partners:
KRN66973.1
Integral membrane protein.
 
     0.788
KRN66744.1
Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
  0.688
KRN66745.1
Ribonucleotide-diphosphate reductase subunit beta.
   
 
  0.643
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
    
 0.640
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
   
 
  0.637
KRN64920.1
HAD-superfamily subfamily IIA hydrolase.
   
 
 0.636
tdk
Thymidine kinase.
     
 0.636
KRN66760.1
Deoxyuridine 5-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
     
  0.625
KRN67472.1
dCMP deaminase.
     
  0.600
KRN65609.1
HAD superfamily hydrolase.
  
 
  0.588
Your Current Organism:
Pediococcus cellicola
NCBI taxonomy Id: 319652
Other names: AS 1.3787, DSM 17757, JCM 14152, LMG 22956, LMG:22956, P. cellicola, Pediococcus cellicola Zhang et al. 2005, Pediococcus sp. Z-1, Pediococcus sp. Z-8, strain Z-8
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