STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Dgeo_0348KEGG: syf:Synpcc7942_2420 serine O-acetyltransferase, ev=7e-29, 45% identity. (171 aa)    
Predicted Functional Partners:
Dgeo_1657
TIGRFAM: cysteine synthases: (8.1e-200) cysteine synthase A: (4.6e-208); PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit: (2.9e-117); KEGG: dra:DR0789 O-acetylserine (thiol)-lyase, ev=1e-153, 83% identity; Belongs to the cysteine synthase/cystathionine beta- synthase family.
 
 0.996
cysS
KEGG: dra:DR1670 cysteinyl-tRNA synthetase, ev=0.0, 75% identity; TIGRFAM: cysteinyl-tRNA synthetase: (1.3e-179); PFAM: cysteinyl-tRNA synthetase, class Ia: (4.2e-149); Belongs to the class-I aminoacyl-tRNA synthetase family.
 
  
 0.963
Dgeo_0343
Undecaprenyl-phosphate galactosephosphotransferase; PFAM: sugar transferase: (1.2e-86); KEGG: dra:DRA0034 UDP-galactose-lipid carrier transferase, ev=1e-175, 64% identity.
  
  
 0.918
Dgeo_1331
TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit: (2.6e-67); PFAM: serine dehydratase alpha chain: (3.4e-152); KEGG: dra:DR0377 L-serine dehydratase, alpha subunit, ev=1e-149, 90% identity.
     
 0.908
Dgeo_1332
TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit: (4.6e-59); PFAM: amino acid-binding ACT: (0.0055) serine dehydratase beta chain: (5.9e-65); KEGG: dra:DR0497 L-serine dehydratase, beta subunit, ev=1e-102, 85% identity.
     
 0.908
Dgeo_0344
PFAM: polysaccharide biosynthesis protein: (9.1e-22); KEGG: ava:Ava_1044 polysaccharide biosynthesis protein, ev=5e-17, 24% identity.
  
  
 0.865
ilvA
Threonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
 
  
 0.845
Dgeo_0610
PFAM: homoserine dehydrogenase: (1.5e-46) homoserine dehydrogenase, NAD-binding: (2.2e-15); KEGG: dra:DR1278 homoserine dehydrogenase, ev=1e-138, 76% identity.
  
  
 0.841
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.837
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
     
 0.834
Your Current Organism:
Deinococcus geothermalis
NCBI taxonomy Id: 319795
Other names: D. geothermalis DSM 11300, Deinococcus geothermalis AG-3a, Deinococcus geothermalis CIP 105573, Deinococcus geothermalis DSM 11300, Deinococcus geothermalis str. DSM 11300, Deinococcus geothermalis strain DSM 11300
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