node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dgeo_0003 | Dgeo_0868 | Dgeo_0003 | Dgeo_0868 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: UvrD/REP helicase: (1.3e-196); KEGG: dra:DR1775 DNA helicase II, ev=0.0, 82% identity. | 0.842 |
Dgeo_0003 | Dgeo_1226 | Dgeo_0003 | Dgeo_1226 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | HRDC domain protein; PFAM: helicase-like: (4.9e-10) HRDC: (5e-23); KEGG: dra:DR1289 DNA helicase RecQ, ev=1e-31, 76% identity. | 0.622 |
Dgeo_0003 | polA | Dgeo_0003 | Dgeo_1666 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.999 |
Dgeo_0003 | recA | Dgeo_0003 | Dgeo_2138 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.834 |
Dgeo_0003 | topA | Dgeo_0003 | Dgeo_2001 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.755 |
Dgeo_0868 | Dgeo_0003 | Dgeo_0868 | Dgeo_0003 | PFAM: UvrD/REP helicase: (1.3e-196); KEGG: dra:DR1775 DNA helicase II, ev=0.0, 82% identity. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.842 |
Dgeo_0868 | Dgeo_1226 | Dgeo_0868 | Dgeo_1226 | PFAM: UvrD/REP helicase: (1.3e-196); KEGG: dra:DR1775 DNA helicase II, ev=0.0, 82% identity. | HRDC domain protein; PFAM: helicase-like: (4.9e-10) HRDC: (5e-23); KEGG: dra:DR1289 DNA helicase RecQ, ev=1e-31, 76% identity. | 0.719 |
Dgeo_0868 | Dgeo_2136 | Dgeo_0868 | Dgeo_2136 | PFAM: UvrD/REP helicase: (1.3e-196); KEGG: dra:DR1775 DNA helicase II, ev=0.0, 82% identity. | TIGRFAM: Competence-damaged protein: (1.5e-68); PFAM: molybdopterin binding domain: (1.1e-55) CinA-like: (5.7e-09); KEGG: dra:DR2338 cinA protein, ev=1e-168, 76% identity; Belongs to the CinA family. | 0.486 |
Dgeo_0868 | polA | Dgeo_0868 | Dgeo_1666 | PFAM: UvrD/REP helicase: (1.3e-196); KEGG: dra:DR1775 DNA helicase II, ev=0.0, 82% identity. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.768 |
Dgeo_0868 | radA | Dgeo_0868 | Dgeo_1212 | PFAM: UvrD/REP helicase: (1.3e-196); KEGG: dra:DR1775 DNA helicase II, ev=0.0, 82% identity. | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.725 |
Dgeo_0868 | recA | Dgeo_0868 | Dgeo_2138 | PFAM: UvrD/REP helicase: (1.3e-196); KEGG: dra:DR1775 DNA helicase II, ev=0.0, 82% identity. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.873 |
Dgeo_0868 | topA | Dgeo_0868 | Dgeo_2001 | PFAM: UvrD/REP helicase: (1.3e-196); KEGG: dra:DR1775 DNA helicase II, ev=0.0, 82% identity. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.757 |
Dgeo_1226 | Dgeo_0003 | Dgeo_1226 | Dgeo_0003 | HRDC domain protein; PFAM: helicase-like: (4.9e-10) HRDC: (5e-23); KEGG: dra:DR1289 DNA helicase RecQ, ev=1e-31, 76% identity. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.622 |
Dgeo_1226 | Dgeo_0868 | Dgeo_1226 | Dgeo_0868 | HRDC domain protein; PFAM: helicase-like: (4.9e-10) HRDC: (5e-23); KEGG: dra:DR1289 DNA helicase RecQ, ev=1e-31, 76% identity. | PFAM: UvrD/REP helicase: (1.3e-196); KEGG: dra:DR1775 DNA helicase II, ev=0.0, 82% identity. | 0.719 |
Dgeo_1226 | polA | Dgeo_1226 | Dgeo_1666 | HRDC domain protein; PFAM: helicase-like: (4.9e-10) HRDC: (5e-23); KEGG: dra:DR1289 DNA helicase RecQ, ev=1e-31, 76% identity. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.908 |
Dgeo_1226 | recA | Dgeo_1226 | Dgeo_2138 | HRDC domain protein; PFAM: helicase-like: (4.9e-10) HRDC: (5e-23); KEGG: dra:DR1289 DNA helicase RecQ, ev=1e-31, 76% identity. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.805 |
Dgeo_1226 | topA | Dgeo_1226 | Dgeo_2001 | HRDC domain protein; PFAM: helicase-like: (4.9e-10) HRDC: (5e-23); KEGG: dra:DR1289 DNA helicase RecQ, ev=1e-31, 76% identity. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.873 |
Dgeo_1366 | Dgeo_2136 | Dgeo_1366 | Dgeo_2136 | LexA-like repressor; PFAM: helix-turn-helix motif: (2.6e-09) peptidase S24, S26A and S26B: (9.8e-12); KEGG: det:DET0884 transcriptional repressor LexA, putative, ev=4e-09, 27% identity. | TIGRFAM: Competence-damaged protein: (1.5e-68); PFAM: molybdopterin binding domain: (1.1e-55) CinA-like: (5.7e-09); KEGG: dra:DR2338 cinA protein, ev=1e-168, 76% identity; Belongs to the CinA family. | 0.524 |
Dgeo_1366 | polA | Dgeo_1366 | Dgeo_1666 | LexA-like repressor; PFAM: helix-turn-helix motif: (2.6e-09) peptidase S24, S26A and S26B: (9.8e-12); KEGG: det:DET0884 transcriptional repressor LexA, putative, ev=4e-09, 27% identity. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.487 |
Dgeo_1366 | recA | Dgeo_1366 | Dgeo_2138 | LexA-like repressor; PFAM: helix-turn-helix motif: (2.6e-09) peptidase S24, S26A and S26B: (9.8e-12); KEGG: det:DET0884 transcriptional repressor LexA, putative, ev=4e-09, 27% identity. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.963 |