node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFA55694.1 | SFA61400.1 | SAMN05216263_106150 | SAMN05216263_109196 | Acetolactate synthase-1/2/3 large subunit. | 5-guanidino-2-oxopentanoate decarboxylase; Belongs to the TPP enzyme family. | 0.524 |
SFA55694.1 | SFA62514.1 | SAMN05216263_106150 | SAMN05216263_110211 | Acetolactate synthase-1/2/3 large subunit. | Homoserine dehydrogenase. | 0.992 |
SFA55694.1 | SFA67738.1 | SAMN05216263_106150 | SAMN05216263_1316 | Acetolactate synthase-1/2/3 large subunit. | Acetolactate synthase, small subunit. | 0.983 |
SFA55694.1 | edd | SAMN05216263_106150 | SAMN05216263_118110 | Acetolactate synthase-1/2/3 large subunit. | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 0.765 |
SFA55694.1 | ilvC | SAMN05216263_106150 | SAMN05216263_1314 | Acetolactate synthase-1/2/3 large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.956 |
SFA55694.1 | ilvD | SAMN05216263_106150 | SAMN05216263_101225 | Acetolactate synthase-1/2/3 large subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.804 |
SFA55694.1 | leuB | SAMN05216263_106150 | SAMN05216263_103305 | Acetolactate synthase-1/2/3 large subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.782 |
SFA55694.1 | leuC | SAMN05216263_106150 | SAMN05216263_103308 | Acetolactate synthase-1/2/3 large subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.785 |
SFA55694.1 | leuD | SAMN05216263_106150 | SAMN05216263_103307 | Acetolactate synthase-1/2/3 large subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.831 |
SFA61400.1 | SFA55694.1 | SAMN05216263_109196 | SAMN05216263_106150 | 5-guanidino-2-oxopentanoate decarboxylase; Belongs to the TPP enzyme family. | Acetolactate synthase-1/2/3 large subunit. | 0.524 |
SFA61400.1 | SFA62514.1 | SAMN05216263_109196 | SAMN05216263_110211 | 5-guanidino-2-oxopentanoate decarboxylase; Belongs to the TPP enzyme family. | Homoserine dehydrogenase. | 0.992 |
SFA61400.1 | SFA67738.1 | SAMN05216263_109196 | SAMN05216263_1316 | 5-guanidino-2-oxopentanoate decarboxylase; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit. | 0.988 |
SFA61400.1 | SFA67740.1 | SAMN05216263_109196 | SAMN05216263_1317 | 5-guanidino-2-oxopentanoate decarboxylase; Belongs to the TPP enzyme family. | Acetolactate synthase, large subunit. | 0.573 |
SFA61400.1 | edd | SAMN05216263_109196 | SAMN05216263_118110 | 5-guanidino-2-oxopentanoate decarboxylase; Belongs to the TPP enzyme family. | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 0.775 |
SFA61400.1 | ilvC | SAMN05216263_109196 | SAMN05216263_1314 | 5-guanidino-2-oxopentanoate decarboxylase; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.961 |
SFA61400.1 | ilvD | SAMN05216263_109196 | SAMN05216263_101225 | 5-guanidino-2-oxopentanoate decarboxylase; Belongs to the TPP enzyme family. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.898 |
SFA61400.1 | leuB | SAMN05216263_109196 | SAMN05216263_103305 | 5-guanidino-2-oxopentanoate decarboxylase; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.874 |
SFA61400.1 | leuC | SAMN05216263_109196 | SAMN05216263_103308 | 5-guanidino-2-oxopentanoate decarboxylase; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.845 |
SFA61400.1 | leuD | SAMN05216263_109196 | SAMN05216263_103307 | 5-guanidino-2-oxopentanoate decarboxylase; Belongs to the TPP enzyme family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.879 |
SFA62514.1 | SFA55694.1 | SAMN05216263_110211 | SAMN05216263_106150 | Homoserine dehydrogenase. | Acetolactate synthase-1/2/3 large subunit. | 0.992 |