purA protein (Campylobacter fetus) - STRING interaction network

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Score

purA

Adenylosuccinate synthetase. (417 aa)

Predicted Functional Partners:

guaB

0.981

purB

0.975

purB2

0.962

purH

0.859

guaA

0.857

purF

0.817

rplK

0.816

hisZ

0.809

glyA

0.809

carB

0.804

Your Current Organism:

Campylobacter fetus

NCBI taxonomy Id: 32019
Other names: C. fetus subsp. fetus, Campylobacter fetus fetus, Campylobacter fetus subsp. fetus, Vibrio fetus subsp. intestinalis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
carB	glyA	ERS672215_00679	ERS672215_01334	Carbamoyl phosphate synthase large subunit; Belongs to the CarB family.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.598
carB	guaA	ERS672215_00679	ERS672215_01732	Carbamoyl phosphate synthase large subunit; Belongs to the CarB family.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.736
carB	guaB	ERS672215_00679	ERS672215_00943	Carbamoyl phosphate synthase large subunit; Belongs to the CarB family.	Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.744
carB	purA	ERS672215_00679	ERS672215_00239	Carbamoyl phosphate synthase large subunit; Belongs to the CarB family.	Adenylosuccinate synthetase.	0.804
carB	purB	ERS672215_00679	ERS672215_00990	Carbamoyl phosphate synthase large subunit; Belongs to the CarB family.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.463
carB	purB2	ERS672215_00679	ERS672215_00444	Carbamoyl phosphate synthase large subunit; Belongs to the CarB family.	Adenylosuccinate lyase.	0.463
carB	purF	ERS672215_00679	ERS672215_00697	Carbamoyl phosphate synthase large subunit; Belongs to the CarB family.	Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.844
carB	purH	ERS672215_00679	ERS672215_00326	Carbamoyl phosphate synthase large subunit; Belongs to the CarB family.	Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.	0.603
glyA	carB	ERS672215_01334	ERS672215_00679	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Carbamoyl phosphate synthase large subunit; Belongs to the CarB family.	0.598
glyA	guaA	ERS672215_01334	ERS672215_01732	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.799
glyA	guaB	ERS672215_01334	ERS672215_00943	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.842
glyA	purA	ERS672215_01334	ERS672215_00239	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Adenylosuccinate synthetase.	0.809
glyA	purB	ERS672215_01334	ERS672215_00990	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.682
glyA	purB2	ERS672215_01334	ERS672215_00444	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Adenylosuccinate lyase.	0.682
glyA	purF	ERS672215_01334	ERS672215_00697	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.789
glyA	purH	ERS672215_01334	ERS672215_00326	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.	0.950
guaA	carB	ERS672215_01732	ERS672215_00679	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Carbamoyl phosphate synthase large subunit; Belongs to the CarB family.	0.736
guaA	glyA	ERS672215_01732	ERS672215_01334	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.799
guaA	guaB	ERS672215_01732	ERS672215_00943	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.999
guaA	hisZ	ERS672215_01732	ERS672215_00238	GMP synthase; Catalyzes the synthesis of GMP from XMP.	ATP phosphoribosyltransferase regulatory subunit.	0.583