STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Cooccurrence
Coexpression
Experiments
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[Homology]
Score
thiSThiamine biosynthesis protein (ThiS); Conserved hypothetical protein called by Glimmer 2; psort: bacterial cytoplasm --- Certainty= 0.230(Affirmative); COG2104 ThiS Sulfur transfer protein involved in thiamine biosynthesis. (69 aa)    
Predicted Functional Partners:
thiG
Thiazole biosynthesis protein (thiG); Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 
 0.993
thiF
Thiamine biosynthesis protein (thiF); Psort: bacterial outside --- Certainty= 0.300(Affirmative); COG0476 ThiF dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2.
  
 
 0.915
thiE
Thiamin monophosphate synthase (thiE); Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.894
thiC
Thiamin biosynthesis protein (thiC); Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
  
  
 0.881
thiD
Phosphomethylpyrimidine kinase (thiD); Psort: bacterial inner membrane --- Certainty= 0.206(Affirmative); COG0351 ThiD hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
  
  
 0.860
thiO
Thiamine biosynthesis oxidoreductase (thiO); Psort: bacterial periplasmic space --- Certainty= 0.711(Affirmative); COG0665 DadA Glycine/D-amino acid oxidases (deaminating).
 
  
 0.759
AMF_021
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.234(Affirmative); signalP: Prediction: Signal peptide Signal peptide probability: 0.646 Max cleavage site probability: 0.575 between pos. 27 and 28.
  
     0.650
AMF_602
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; Possible type IV secretion system protein (virB6); psort: bacterial inner membrane --- Certainty= 0.722(Affirmative); COG3704 Type IV secretory pathway, VirB6 components.
  
     0.613
AMF_1007
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.346(Affirmative).
  
    0.603
AMF_604
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; Possible type IV secretion system protein (virB6); psort: bacterial inner membrane --- Certainty= 0.675(Affirmative); COG3704 Type IV secretory pathway, VirB6 components.
  
     0.573
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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