| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| carB | guaA | AMF_716 | AMF_897 | Carbamyl-phosphate synthase, large subunit (carB); Psort: bacterial inner membrane --- Certainty= 0.157(Affirmative); COG0458 CarB carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | 0.817 |
| carB | guaB | AMF_716 | AMF_073 | Carbamyl-phosphate synthase, large subunit (carB); Psort: bacterial inner membrane --- Certainty= 0.157(Affirmative); COG0458 CarB carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. | Inosine monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.832 |
| carB | pheT | AMF_716 | AMF_670 | Carbamyl-phosphate synthase, large subunit (carB); Psort: bacterial inner membrane --- Certainty= 0.157(Affirmative); COG0458 CarB carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. | phenylalanyl-tRNA synthetase beta chain (pheT); Psort: bacterial inner membrane --- Certainty= 0.193(Affirmative); COG0072 PheT phenylalanyl-tRNA synthetase beta subunit. | 0.519 |
| carB | purH | AMF_716 | AMF_831 | Carbamyl-phosphate synthase, large subunit (carB); Psort: bacterial inner membrane --- Certainty= 0.157(Affirmative); COG0458 CarB carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase)(purH); Psort: bacterial inner membrane --- Certainty= 0.162(Affirmative); COG0138 PurH AICAR transformylase/IMP cyclohydrolase PurH. | 0.475 |
| carB | purL | AMF_716 | AMF_743 | Carbamyl-phosphate synthase, large subunit (carB); Psort: bacterial inner membrane --- Certainty= 0.157(Affirmative); COG0458 CarB carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. | Phosphoribosylformylglycinamidine synthase (PurL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to ass [...] | 0.813 |
| carB | pyrG | AMF_716 | AMF_015 | Carbamyl-phosphate synthase, large subunit (carB); Psort: bacterial inner membrane --- Certainty= 0.157(Affirmative); COG0458 CarB carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. | CTP synthase (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.826 |
| guaA | carB | AMF_897 | AMF_716 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | Carbamyl-phosphate synthase, large subunit (carB); Psort: bacterial inner membrane --- Certainty= 0.157(Affirmative); COG0458 CarB carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. | 0.817 |
| guaA | guaB | AMF_897 | AMF_073 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | Inosine monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | pheT | AMF_897 | AMF_670 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | phenylalanyl-tRNA synthetase beta chain (pheT); Psort: bacterial inner membrane --- Certainty= 0.193(Affirmative); COG0072 PheT phenylalanyl-tRNA synthetase beta subunit. | 0.936 |
| guaA | purA-2 | AMF_897 | AMF_641 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.806 |
| guaA | purB | AMF_897 | AMF_279 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate lyase protein (purB); Psort: bacterial inner membrane --- Certainty= 0.185(Affirmative); COG0015 PurB adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.851 |
| guaA | purH | AMF_897 | AMF_831 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | Phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase)(purH); Psort: bacterial inner membrane --- Certainty= 0.162(Affirmative); COG0138 PurH AICAR transformylase/IMP cyclohydrolase PurH. | 0.875 |
| guaA | purL | AMF_897 | AMF_743 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformylglycinamidine synthase (PurL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to ass [...] | 0.913 |
| guaA | pyrG | AMF_897 | AMF_015 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | CTP synthase (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.991 |
| guaA | surE | AMF_897 | AMF_331 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | Stationary-phase survival protein (surE); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.958 |
| guaB | carB | AMF_073 | AMF_716 | Inosine monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Carbamyl-phosphate synthase, large subunit (carB); Psort: bacterial inner membrane --- Certainty= 0.157(Affirmative); COG0458 CarB carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. | 0.832 |
| guaB | guaA | AMF_073 | AMF_897 | Inosine monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | 0.999 |
| guaB | pheT | AMF_073 | AMF_670 | Inosine monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | phenylalanyl-tRNA synthetase beta chain (pheT); Psort: bacterial inner membrane --- Certainty= 0.193(Affirmative); COG0072 PheT phenylalanyl-tRNA synthetase beta subunit. | 0.873 |
| guaB | purA-2 | AMF_073 | AMF_641 | Inosine monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.978 |
| guaB | purB | AMF_073 | AMF_279 | Inosine monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate lyase protein (purB); Psort: bacterial inner membrane --- Certainty= 0.185(Affirmative); COG0015 PurB adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.894 |