STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
purFAmidophosphoribosyltransferase (purF); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (469 aa)    
Predicted Functional Partners:
purQ
Phosphoribosylformylglycinamidine synthase I (purQ); Psort: bacterial inner membrane --- Certainty= 0.177(Affirmative); COG0046 PurL phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain.
 
 
 0.996
purD
Phosphoribosylamine-glycine ligase (purD); Psort: bacterial cytoplasm --- Certainty= 0.188(Affirmative); COG0151 PurD phosphoribosylamine-glycine ligase; Belongs to the GARS family.
 
 0.996
purM
Phosphoribosylaminoimidazole synthetase (AIR synthetase) (purM); Psort: bacterial cytoplasm --- Certainty= 0.099(Affirmative); COG0150 PurM phosphoribosylaminoimidazol (AIR) synthetase.
  
 0.993
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase)(purH); Psort: bacterial inner membrane --- Certainty= 0.162(Affirmative); COG0138 PurH AICAR transformylase/IMP cyclohydrolase PurH.
  
 
 0.992
purB
Adenylosuccinate lyase protein (purB); Psort: bacterial inner membrane --- Certainty= 0.185(Affirmative); COG0015 PurB adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 
 0.987
purK
Phosphoribosylaminoimidazole carboxylase (purK); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
  
 
 0.987
carB
Carbamyl-phosphate synthase, large subunit (carB); Psort: bacterial inner membrane --- Certainty= 0.157(Affirmative); COG0458 CarB carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family.
  
 
 0.983
carA
Carbamoyl-phosphate synthase, small chain (carA); Psort: bacterial inner membrane --- Certainty= 0.210(Affirmative); COG0505 CarA carbamoylphosphate synthase small subunit; Belongs to the CarA family.
  
 
 0.966
purC
Phosphoribosoylaminoimidazole-succinocarboxamide synthase (purC); Psort: bacterial cytoplasm --- Certainty= 0.378(Affirmative); COG0152 PurC phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family.
  
 
 0.965
purL
Phosphoribosylformylglycinamidine synthase (PurL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to ass [...]
 
 0.965
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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