STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aprEAlkaline protease secretion protein (aprE); Psort: bacterial inner membrane --- Certainty= 0.569(Affirmative); COG1404 aprE subtilisin-like serine proteases. (512 aa)    
Predicted Functional Partners:
tolC
Outer membrane protein (tolC); Psort: bacterial inner membrane --- Certainty= 0.295(Affirmative); COG1538 TolC outer membrane protein.
 
 
 0.982
aprD
Alkaline protease secretion ATP-binding protein (aprD); Psort: bacterial inner membrane --- Certainty= 0.478(Affirmative); COG1132 MdlB ABC-type multidrug/protein/lipid transport system, ATPase component.
  
 0.949
coxB
Cytochrome c oxidase subunit II (coxB); Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
 
    
 0.791
coxA
Cytochrome c oxidase subunit I (coxA); Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
 
      0.775
phnL
ATP transporter ATP-binding protein (phnL); Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
  
 
 0.686
dhkA
Sensory box histidine kinase/response regulator (dhkA); Psort: bacterial inner membrane --- Certainty= 0.491(Affirmative); COG0642 Signal transduction histidine kinase.
 
  
 0.584
AMF_176
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial cytoplasm --- Certainty= 0.326(Affirmative).
       0.554
hlyD
Putative secretion protein hlyD; Psort: bacterial cytoplasm --- Certainty= 0.244(Affirmative); COG0845 AcrA Membrane-fusion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
  
 0.533
bcr2
Bicyclomycin resistance protein (bcr2); Psort: bacterial inner membrane --- Certainty= 0.459(Affirmative).
 
 
 0.515
polA
DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.488
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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