STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rnhBRibonuclease HII (rnhB); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (339 aa)    
Predicted Functional Partners:
dnaN
DNA polymerase III beta chain (dnaN); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiatio [...]
   
 
 0.940
rnhA
Ribonuclease H (rnhA); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
   
 
 0.931
polA
DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 
 0.804
guaB
Inosine monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
     
 0.748
AMF_624
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.037(Affirmative); COG3298 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB.
   
 
 0.692
dnaE
DNA polymerase III, alpha subunit (dnaE); Psort: bacterial inner membrane --- Certainty= 0.113(Affirmative); COG0587 DnaE DNA polymerase III alpha subunit.
  
  
 0.690
ndk
Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
      
 0.690
xerD
Tyrosine recombinase (xerD); Psort: bacterial inner membrane --- Certainty= 0.285(Affirmative); COG0582 XerC integrase; Belongs to the 'phage' integrase family.
     
 0.661
recA
recA protein (recA); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.636
rpmE
50S ribosomal protein L31 (LSU/L31) (rpmE); Psort: bacterial cytoplasm --- Certainty= 0.229(Affirmative); COG0254 RpmE ribosomal protein L31.
     
 0.633
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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