STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdhDSuccinate dehyrdrogenase subunit D; Psort: bacterial inner membrane --- Certainty= 0.408(Affirmative); COG2142 SdhD succinate dehydrogenase hydrophobic anchor subunit. (116 aa)    
Predicted Functional Partners:
sdhC
Succinate dehydrogenase cytochrome b556 subunit (sdhC); Psort: bacterial inner membrane --- Certainty= 0.508(Affirmative); COG2009 SdhC succinate dehydrogenase/fumarate reductase cytochrome b subunit.
 
 0.999
sdhB
Succinate dehydrogenase iron-sulfur protein (sdhB/frdB); Psort: bacterial cytoplasm --- Certainty= 0.392(Affirmative); COG0479 FrdB succinate dehydrogenase/fumarate reductase Fe-S protein.
  
 0.998
sdhA
Succinate dehydrogenase flavoprotein subunit (sdhA/frdA); Psort: bacterial inner membrane --- Certainty= 0.202(Affirmative); COG1053 SdhA succinate dehydrogenase/fumarate reductase, flavoprotein subunits; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
  
 0.996
sucC
succinyl-CoA synthetase beta chain (sucC); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.986
sucD
succinyl-CoA ligase chain A (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.951
fumC
Fumarate hydratase (fumC); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
   
 
 0.916
sucA
2-oxoglutarate dehydrogenase E1 component (sucA); Psort: bacterial cytoplasm --- Certainty= 0.276(Affirmative); COG0567 SucA pyruvate and 2-oxoglutarate dehydrogenases, E1 component.
  
  
 0.868
aatA
Aspartate aminotransferase A (aatA); Psort: bacterial cytoplasm --- Certainty= 0.178(Affirmative); COG0075 - serine-pyruvate aminotransferase/archaeal aspartate aminotransferase.
     
  0.800
AMF_829
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial periplasmic space --- Certainty= 0.944(Affirmative).
  
     0.671
AMF_849
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.365(Affirmative).
  
     0.633
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.