STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurrence
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[Homology]
Score
thiEThiamin monophosphate synthase (thiE); Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (340 aa)    
Predicted Functional Partners:
thiD
Phosphomethylpyrimidine kinase (thiD); Psort: bacterial inner membrane --- Certainty= 0.206(Affirmative); COG0351 ThiD hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
 
 0.999
thiG
Thiazole biosynthesis protein (thiG); Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 0.997
thiL
Thiamin-monophosphate kinase (thiL); Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
    
 0.941
thiC
Thiamin biosynthesis protein (thiC); Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
  
  
 0.930
thiS
Thiamine biosynthesis protein (ThiS); Conserved hypothetical protein called by Glimmer 2; psort: bacterial cytoplasm --- Certainty= 0.230(Affirmative); COG2104 ThiS Sulfur transfer protein involved in thiamine biosynthesis.
 
  
 0.895
thiF
Thiamine biosynthesis protein (thiF); Psort: bacterial outside --- Certainty= 0.300(Affirmative); COG0476 ThiF dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2.
  
  
 0.751
thiO
Thiamine biosynthesis oxidoreductase (thiO); Psort: bacterial periplasmic space --- Certainty= 0.711(Affirmative); COG0665 DadA Glycine/D-amino acid oxidases (deaminating).
 
  
 0.671
guaB
Inosine monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 
 0.639
purA
Adenylosuccinate synthetase (purA); C-terminal end of the full-length purA; psort: bacterial cytoplasm --- Certainty= 0.325(Affirmative); COG0104 PurA Adenylosuccinate synthase.
      
 0.569
purA-2
Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
      
 0.569
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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