STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucA2-oxoglutarate dehydrogenase E1 component (sucA); Psort: bacterial cytoplasm --- Certainty= 0.276(Affirmative); COG0567 SucA pyruvate and 2-oxoglutarate dehydrogenases, E1 component. (930 aa)    
Predicted Functional Partners:
sucB
Dihydrolipoamide acetyltransferase component (sucB); Psort: bacterial inner membrane --- Certainty= 0.238(Affirmative); COG0508 AceF dihydrolipoamide acyltransferases.
 
 0.999
pdhD
Dihydrolipoamide dehydrogenase (pdhD); Psort: bacterial inner membrane --- Certainty= 0.117(Affirmative).
  
 0.990
lpdA
Dihydrolipoamide dehydrogenase (lpdA); Psort: bacterial membrane --- Certainty= 0.512(Affirmative); COG1249 Lpd dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymes.
  
 0.990
pdhC
Dihydrolipoamide acetyltransferase component (pdhC); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.987
sucC
succinyl-CoA synthetase beta chain (sucC); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.985
sucD
succinyl-CoA ligase chain A (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.978
gltA
Citrate synthase (gltA); Psort: bacterial cytoplasm --- Certainty= 0.043(Affirmative); COG0372 GltA citrate synthase.
  
 0.960
icd
Isocitrate dehydrogenase (icd); Psort: bacterial cytoplasm --- Certainty= 0.104(Affirmative); COG0538 Icd isocitrate dehydrogenases.
   
 0.959
sdhB
Succinate dehydrogenase iron-sulfur protein (sdhB/frdB); Psort: bacterial cytoplasm --- Certainty= 0.392(Affirmative); COG0479 FrdB succinate dehydrogenase/fumarate reductase Fe-S protein.
  
 
 0.929
sdhA
Succinate dehydrogenase flavoprotein subunit (sdhA/frdA); Psort: bacterial inner membrane --- Certainty= 0.202(Affirmative); COG1053 SdhA succinate dehydrogenase/fumarate reductase, flavoprotein subunits; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
  
 
 0.922
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.