STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadDNicotinate-nucleotide adenylyltransferase (nadD); Psort: bacterial inner membrane --- Certainty= 0.268(Affirmative); COG1057 NadD Nicotinic acid mononucleotide adenylyltransferase. (234 aa)    
Predicted Functional Partners:
cinA
Competence / damage-inducible protein (cinA); Psort: bacterial inner membrane --- Certainty= 0.304(Affirmative); COG1058 CinA predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA.
 
 
 0.952
nadE
NH3-dependent NAD+ synthetase protein (nadE); Psort: bacterial inner membrane --- Certainty= 0.172(Affirmative); COG0171 NadE NAD synthase; Belongs to the NAD synthetase family.
  
 
 0.943
nadK
Conserved family ATP-NAD kinase called by Glimmer 2; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.942
nadC
Nicotinate-nucleotide pyrophosphorylase (nadC); Psort: bacterial cytoplasm --- Certainty= 0.379(Affirmative); COG0157 NadC nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family.
    
 0.939
surE
Stationary-phase survival protein (surE); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
rsfS
Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
 
  
 0.786
ribD
Riboflavin biosynthesis protein (ribD); Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
  
 0.724
pdxJ
Pyridoxal phosphate biosynthetic protein (pdxJ); Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
 
   
 0.632
AMF_315
Hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.450(Affirmative).
       0.552
nnrD
Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...]
   
  
 0.547
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.