Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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thiCThiamin biosynthesis protein (thiC); Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (600 aa)    
Predicted Functional Partners:
thiD
Phosphomethylpyrimidine kinase (thiD); Psort: bacterial inner membrane --- Certainty= 0.206(Affirmative); COG0351 ThiD hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
  
 
 0.990
thiG
Thiazole biosynthesis protein (thiG); Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
  
 0.926
thiE
Thiamin monophosphate synthase (thiE); Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.925
thiS
Thiamine biosynthesis protein (ThiS); Conserved hypothetical protein called by Glimmer 2; psort: bacterial cytoplasm --- Certainty= 0.230(Affirmative); COG2104 ThiS Sulfur transfer protein involved in thiamine biosynthesis.
  
  
 0.881
purM
Phosphoribosylaminoimidazole synthetase (AIR synthetase) (purM); Psort: bacterial cytoplasm --- Certainty= 0.099(Affirmative); COG0150 PurM phosphoribosylaminoimidazol (AIR) synthetase.
     
  0.800
purK
Phosphoribosylaminoimidazole carboxylase (purK); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
     
  0.800
thiF
Thiamine biosynthesis protein (thiF); Psort: bacterial outside --- Certainty= 0.300(Affirmative); COG0476 ThiF dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2.
  
  
 0.777
AMF_323
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial cytoplasm --- Certainty= 0.298(Affirmative); COG2840 Uncharacterized BCR.
       0.650
bioB
Biotin synthase (bioB); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
  
 0.558
putA-2
1-pyrroline-5-carboxylate dehydrogenase (putA); N-terminal end of AMF_435 (putA); psort: bacterial cytoplasm --- Certainty= 0.539(Affirmative); COG1012 PutA NAD-dependent aldehyde dehydrogenase.
      
 0.520
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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