STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
surEStationary-phase survival protein (surE); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (261 aa)    
Predicted Functional Partners:
guaB
Inosine monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 0.960
guaA
GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP.
    
 0.958
pyrH
Uridylate kinase (pyrH); Catalyzes the reversible phosphorylation of UMP to UDP.
     
 0.933
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase)(purH); Psort: bacterial inner membrane --- Certainty= 0.162(Affirmative); COG0138 PurH AICAR transformylase/IMP cyclohydrolase PurH.
     
 0.933
purB
Adenylosuccinate lyase protein (purB); Psort: bacterial inner membrane --- Certainty= 0.185(Affirmative); COG0015 PurB adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
    
 0.923
cmk
Cytidylate kinase (cmk); Psort: bacterial cytoplasm --- Certainty= 0.151(Affirmative); COG0283 Cmk cytidylate kinase.
    
 0.923
adk
Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
     
 0.917
pyrF
Orotidine 5'-phosphate decarboxylase (pyrF); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
    
 0.916
tmk
Thymidylate kinase (tmk); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
    
  0.911
purA-2
Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
    
 0.903
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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