STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrdBRibonuceoside-diphosphate reductase beta chain (nrdB); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (343 aa)    
Predicted Functional Partners:
nrdA
Ribonuclease-diphosphate reductase alpha chain (nrdA); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
 
 0.999
tmk
Thymidylate kinase (tmk); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
   
 
 0.934
cmk
Cytidylate kinase (cmk); Psort: bacterial cytoplasm --- Certainty= 0.151(Affirmative); COG0283 Cmk cytidylate kinase.
    
 0.934
adk
Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
     
 0.933
ndk
Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
     
 0.913
gmk
Guanylate kinase (gmk); Essential for recycling GMP and indirectly, cGMP.
     
 0.903
AMF_357
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.448(Affirmative); COG0526 Thiol-disulfide isomerase and thioredoxins.
  
    0.823
gpsA
Gylcerol-3-phosphate dehydrogenase (gpsA); Psort: bacterial inner membrane --- Certainty= 0.191(Affirmative); COG0240 GpsA glycerol 3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
   
  
 0.737
nuoF
NADH dehydrogenase I chain F (nuoF); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family.
   
  
 0.735
ppdK
Pyruvate, phosphate dikinase precursor (ppdK); Psort: bacterial cytoplasm --- Certainty= 0.272(Affirmative); COG0574 PpsA phosphoenolpyruvate synthase/pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family.
      
 0.729
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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