STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrdBRibonuceoside-diphosphate reductase beta chain (nrdB); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (343 aa)    
Predicted Functional Partners:
nrdA
Ribonuclease-diphosphate reductase alpha chain (nrdA); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
 
 0.999
tmk
Thymidylate kinase (tmk); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
   
 
 0.938
adk
Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
     
 0.927
cmk
Cytidylate kinase (cmk); Psort: bacterial cytoplasm --- Certainty= 0.151(Affirmative); COG0283 Cmk cytidylate kinase.
    
 0.922
ndk
Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
     
 0.912
gmk
Guanylate kinase (gmk); Essential for recycling GMP and indirectly, cGMP.
   
 
 0.902
AMF_357
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.448(Affirmative); COG0526 Thiol-disulfide isomerase and thioredoxins.
       0.777
trxA
Thioredoxin (trxA); Posrt: bacterial cytoplasm --- Certainty= 0.097(Affirmative); COG0526 TrxA thiol-disulfide isomerase and thioredoxins; Belongs to the thioredoxin family.
  
 
 0.673
grxC1
Glutaredoxin 3 (grxC1); Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
  
  
 0.532
gpsA
Gylcerol-3-phosphate dehydrogenase (gpsA); Psort: bacterial inner membrane --- Certainty= 0.191(Affirmative); COG0240 GpsA glycerol 3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
   
  
 0.516
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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