| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| guaA | gyrB2 | AMF_897 | AMF_480 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | DNA gyrase subunit B (gyrB2); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.534 |
| guaA | infB | AMF_897 | AMF_423 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | Translation initiation factor IF-2; Psort: bacterial cytoplasm --- Certainty= 0.078(Affirmative); COG0532 translation initiation factor 2 (GTPase). | 0.631 |
| guaA | infB-2 | AMF_897 | AMF_542 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | Translation initiation factor IF-2 (infB); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | 0.631 |
| guaA | nusA | AMF_897 | AMF_543 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | Transcription termination factor nusA (nusA); Participates in both transcription termination and antitermination. | 0.546 |
| guaA | pnp | AMF_897 | AMF_391 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | 0.852 |
| guaA | rimM | AMF_897 | AMF_957 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | 16S rRNA processing protein (rimM); An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. | 0.891 |
| guaA | rpsA | AMF_897 | AMF_701 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | 30S ribosomal protein S1 (rpsA); Psort: bacterial cytoplasm --- Certainty= 0.280(Affirmative); COG0539 RpsA ribosomal protein S1. | 0.828 |
| guaA | rpsO | AMF_897 | AMF_390 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | 30S ribosomal protein S15 (rpsO); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. | 0.770 |
| guaA | truB | AMF_897 | AMF_389 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | tRNA pseudouridine 55 synthase (truB); Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.912 |
| gyrB2 | guaA | AMF_480 | AMF_897 | DNA gyrase subunit B (gyrB2); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | 0.534 |
| gyrB2 | pnp | AMF_480 | AMF_391 | DNA gyrase subunit B (gyrB2); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | 0.419 |
| gyrB2 | rbfA | AMF_480 | AMF_541 | DNA gyrase subunit B (gyrB2); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Ribosome-binding factor A (rbfA); One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. | 0.412 |
| gyrB2 | rpsA | AMF_480 | AMF_701 | DNA gyrase subunit B (gyrB2); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 30S ribosomal protein S1 (rpsA); Psort: bacterial cytoplasm --- Certainty= 0.280(Affirmative); COG0539 RpsA ribosomal protein S1. | 0.400 |
| gyrB2 | rpsO | AMF_480 | AMF_390 | DNA gyrase subunit B (gyrB2); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 30S ribosomal protein S15 (rpsO); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. | 0.437 |
| gyrB2 | truB | AMF_480 | AMF_389 | DNA gyrase subunit B (gyrB2); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | tRNA pseudouridine 55 synthase (truB); Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.816 |
| infB | guaA | AMF_423 | AMF_897 | Translation initiation factor IF-2; Psort: bacterial cytoplasm --- Certainty= 0.078(Affirmative); COG0532 translation initiation factor 2 (GTPase). | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | 0.631 |
| infB | nusA | AMF_423 | AMF_543 | Translation initiation factor IF-2; Psort: bacterial cytoplasm --- Certainty= 0.078(Affirmative); COG0532 translation initiation factor 2 (GTPase). | Transcription termination factor nusA (nusA); Participates in both transcription termination and antitermination. | 0.884 |
| infB | pnp | AMF_423 | AMF_391 | Translation initiation factor IF-2; Psort: bacterial cytoplasm --- Certainty= 0.078(Affirmative); COG0532 translation initiation factor 2 (GTPase). | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | 0.835 |
| infB | rbfA | AMF_423 | AMF_541 | Translation initiation factor IF-2; Psort: bacterial cytoplasm --- Certainty= 0.078(Affirmative); COG0532 translation initiation factor 2 (GTPase). | Ribosome-binding factor A (rbfA); One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. | 0.820 |
| infB | rimM | AMF_423 | AMF_957 | Translation initiation factor IF-2; Psort: bacterial cytoplasm --- Certainty= 0.078(Affirmative); COG0532 translation initiation factor 2 (GTPase). | 16S rRNA processing protein (rimM); An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. | 0.429 |
