Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (317 aa)    
Predicted Functional Partners:
gltA
Citrate synthase (gltA); Psort: bacterial cytoplasm --- Certainty= 0.043(Affirmative); COG0372 GltA citrate synthase.
  
 0.998
fumC
Fumarate hydratase (fumC); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.994
maeB
Malate dehydrogenase and phosphate acetyltransferase (maeB); Psort: bacterial inner membrane --- Certainty= 0.140(Affirmative); COG0039 Mdh malate/lactate dehydrogenases.
  
 0.989
aatA
Aspartate aminotransferase A (aatA); Psort: bacterial cytoplasm --- Certainty= 0.178(Affirmative); COG0075 - serine-pyruvate aminotransferase/archaeal aspartate aminotransferase.
  
 0.966
acnA
Aconitate hydratase (acnA); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.951
atpA
F1-ATP synthase alpha subunit (atpA); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family.
   
 0.934
groEL
60 kD chaperonin (groEL); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
   
 0.918
sucA
2-oxoglutarate dehydrogenase E1 component (sucA); Psort: bacterial cytoplasm --- Certainty= 0.276(Affirmative); COG0567 SucA pyruvate and 2-oxoglutarate dehydrogenases, E1 component.
  
 0.883
fdxA
Ferredoxin II (fdxA); Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
  
  
 0.869
gapA
Psort: bacterial cytoplasm --- Certainty= 0.128(Affirmative); COG0057 GapA glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase.
  
 
 0.868
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.