STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthetase (purA); C-terminal end of the full-length purA; psort: bacterial cytoplasm --- Certainty= 0.325(Affirmative); COG0104 PurA Adenylosuccinate synthase. (71 aa)    
Predicted Functional Partners:
purC
Phosphoribosoylaminoimidazole-succinocarboxamide synthase (purC); Psort: bacterial cytoplasm --- Certainty= 0.378(Affirmative); COG0152 PurC phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family.
  
 
 0.926
purE
Phosphoribosylaminoimidazole carboxylase catalytic subunit (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
 
 0.924
purK
Phosphoribosylaminoimidazole carboxylase (purK); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
  
 
 0.917
purN
Phosphoribosylglycinamide formyl transferase (purN); Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 
 0.870
purB
Adenylosuccinate lyase protein (purB); Psort: bacterial inner membrane --- Certainty= 0.185(Affirmative); COG0015 PurB adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 
 0.845
guaA
GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP.
  
  
 0.825
guaB
Inosine monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.784
AMF_451
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.266(Affirmative).
       0.773
mraW
S-adenosyl-methyltransferase (mraW); Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
       0.773
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase)(purH); Psort: bacterial inner membrane --- Certainty= 0.162(Affirmative); COG0138 PurH AICAR transformylase/IMP cyclohydrolase PurH.
  
 
 0.711
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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