STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthetase (purA); C-terminal end of the full-length purA; psort: bacterial cytoplasm --- Certainty= 0.325(Affirmative); COG0104 PurA Adenylosuccinate synthase. (71 aa)    
Predicted Functional Partners:
purB
Adenylosuccinate lyase protein (purB); Psort: bacterial inner membrane --- Certainty= 0.185(Affirmative); COG0015 PurB adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 
 0.831
guaA
GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP.
  
  
 0.806
guaB
Inosine monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.797
AMF_451
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.266(Affirmative).
       0.773
mraW
S-adenosyl-methyltransferase (mraW); Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
       0.773
glyA
Glycine/serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
  
 0.711
rplK
50S ribosomal protein L11 (rplK); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
  
    0.703
rplC
50S ribosomal protein L3 (rplC); One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
   
    0.692
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase)(purH); Psort: bacterial inner membrane --- Certainty= 0.162(Affirmative); COG0138 PurH AICAR transformylase/IMP cyclohydrolase PurH.
  
 
 0.668
purC
Phosphoribosoylaminoimidazole-succinocarboxamide synthase (purC); Psort: bacterial cytoplasm --- Certainty= 0.378(Affirmative); COG0152 PurC phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family.
  
 
 0.657
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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