STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ygfA5-formyltetrahydrofolate cyclo-ligase; Psort: bacterial cytoplasm --- Certainty= 0.396(Affirmative); COG0212 5-formyltetrahydrofolate cyclo-ligase. (178 aa)    
Predicted Functional Partners:
folD
Methylenetetrahydrofolate dehydrogenase (folD); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.941
purN
Phosphoribosylglycinamide formyl transferase (purN); Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
    
 0.912
lon
ATP-dependent protease LA (lon); ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
     
 0.757
pheT
phenylalanyl-tRNA synthetase beta chain (pheT); Psort: bacterial inner membrane --- Certainty= 0.193(Affirmative); COG0072 PheT phenylalanyl-tRNA synthetase beta subunit.
  
  
 0.594
bolA
bolA like protein (bolA); Psort: bacterial inner membrane --- Certainty= 0.036(Affirmative); COG0271 BolA stress-induced morphogen (activity unknown); Belongs to the BolA/IbaG family.
     
 0.500
dnaK
DNAK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
  
 0.500
purA
Adenylosuccinate synthetase (purA); C-terminal end of the full-length purA; psort: bacterial cytoplasm --- Certainty= 0.325(Affirmative); COG0104 PurA Adenylosuccinate synthase.
   
   0.499
glyA
Glycine/serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.497
mraW
S-adenosyl-methyltransferase (mraW); Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
       0.484
AMF_451
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.266(Affirmative).
       0.461
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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